From the Department of Neurology, Tokyo Metropolitan Geriatric Hospital.
Department of Diagnostic Radiology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.
Clin Nucl Med. 2021 Dec 1;46(12):e582-e583. doi: 10.1097/RLU.0000000000003755.
Two patients with different amyotrophic lateral sclerosis (ALS) phenotypes underwent 18F-THK5351 PET to visualize lesions undergoing astrogliosis by measuring monoamine oxidase B activity. Patient 1 was a 57-year-old man with flail leg syndrome. Elevated uptake was observed inside the motor cortex, corresponding to the leg area in a cortical homunculus. Patient 2 was a 64-year-old man with ALS-frontotemporal dementia semantic variant. Elevated uptake was observed around the left anterior temporal lobe. Both core lesions were consistent with their respective neurological features. Hence, 18F-THK5351 PET is a useful technique to assess ALS pathophysiology by visualizing the core lesions.
两名具有不同肌萎缩侧索硬化症 (ALS) 表型的患者接受了 18F-THK5351 PET 检查，以通过测量单胺氧化酶 B 活性来观察星形胶质细胞增生的病变。患者 1 为 57 岁男性，表现为“连枷腿综合征”。在运动皮质内观察到摄取增加，与皮质小人图中的腿部区域相对应。患者 2 为 64 岁男性，患有 ALS-额颞叶痴呆语义变异型。在左侧前颞叶周围观察到摄取增加。两个核心病变均与各自的神经特征一致。因此，18F-THK5351 PET 是一种通过可视化核心病变来评估 ALS 病理生理学的有用技术。
