Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri, 2, 20156, Milan, Italy.
Clinical Epidemiology and Public Health Research Unit, Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy.
Sci Rep. 2020 Dec 16;10(1):22099. doi: 10.1038/s41598-020-79176-3.
We monitored the burden of cancer in Italy and its trends over the last three decades, providing estimates of cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years (DALYs), for cancer overall and 30 cancer sites using data from the Global Burden of Disease study 2017. An overview of mortality trends between 1990 and 2017 was also provided. In 2017, there were 254,336 new cancer cases in men and 214,994 in women, corresponding to an age-standardized incidence rate (ASIR) of 438 and 330/100,000, respectively. Between 1990 and 2017, incident cancer cases, and, to a lesser extent, ASIRs significantly increased overall and for almost all cancer sites, but ASIRs significantly declined for lung and other tobacco-related neoplasms. In 2017, there were 101,659 cancer deaths in men (age-standardized death rate, ASDR, 158.5/100,000) and 78,918 in women (ASDR 93.9/100,000). Cancer deaths significantly increased between 1990 and 2017 (+ 18%), but ASDR significantly decreased (- 28%). Deaths significantly increased for many cancer sites, but decreased for stomach, esophageal, laryngeal, Hodgkin lymphoma, and testicular cancer. ASDRs significantly decreased for most neoplasms, with the main exceptions of cancer of the pancreas and uterus, and multiple myeloma. In 2017, cancer caused 3,204,000 DALYs. Between 1990 and 2017, DALYs and age-standardized DALY rates significantly declined (-3.4% and -33%, respectively). Age-standardized mortality rates in Italy showed favorable patterns over the last few decades. However, the absolute number of cancer cases and, to a lower extent, of cancer deaths increased likely due to the progressive ageing of the population, this calling for a continuous effort in cancer prevention, early diagnosis, and treatment.
我们监测了意大利过去三十年的癌症负担及其变化趋势，使用 2017 年全球疾病负担研究的数据，对总体癌症和 30 个癌症部位的癌症发病率、死亡率、生命损失年数、失能生命年数和伤残调整生命年数（DALYs）进行了估计。还提供了 1990 年至 2017 年期间死亡率趋势的概述。2017 年，男性有 254336 例新癌症病例，女性有 214994 例，相应的年龄标准化发病率（ASIR）分别为 438 和 330/100000。1990 年至 2017 年间，癌症新发病例数以及在一定程度上 ASIR 总体上显著增加，几乎所有癌症部位均如此，但肺癌和其他与烟草相关的肿瘤的 ASIR 显著下降。2017 年，男性有 101659 例癌症死亡（年龄标准化死亡率，ASDR，158.5/100000），女性有 78918 例（ASDR 93.9/100000）。1990 年至 2017 年间，癌症死亡人数显著增加（+18%），但 ASDR 显著下降（-28%）。许多癌症部位的死亡人数显著增加，但胃癌、食管癌、喉癌、霍奇金淋巴瘤和睾丸癌的死亡人数则有所下降。大多数肿瘤的 ASDR 显著下降，主要例外是胰腺癌和子宫癌以及多发性骨髓瘤。2017 年，癌症导致 3204000 个 DALYs。1990 年至 2017 年间，DALYs 和年龄标准化 DALY 率显著下降（分别为-3.4%和-33%）。过去几十年，意大利的年龄标准化死亡率呈现出有利的模式。然而，由于人口的老龄化，癌症病例的绝对数量以及在一定程度上癌症死亡人数增加，这需要在癌症预防、早期诊断和治疗方面不断努力。
