新型冠状病毒肺炎患者肝功能检查升高：病因、临床证据和潜在治疗方法。
Elevated liver function tests in COVID-19: Causes, clinical evidence, and potential treatments.
机构信息
Ricketta Clark is assistant professor at the University of Tennessee Health Science Center, Memphis, Tenn. Bradford Waters is Professor of Medicine, University of Tennessee Health Science Center, Memphis, Tenn., and section chief, Gastroenterology, Memphis VA Medical Center, Memphis, Tenn. Ansley Grimes Stanfill is Associate Dean of Research and associate professor at the University of Tennessee Health Science Center, Memphis, Tenn.
出版信息
Nurse Pract. 2021 Jan 1;46(1):21-26. doi: 10.1097/01.NPR.0000722316.63824.f9.
Abstract
COVID-19 causes severe respiratory and multiorgan failure, including liver damage and elevated transaminase levels. This article addresses the potential causes of liver function abnormalities in patients diagnosed with COVID-19 and management approaches for NPs focusing on preventing and alleviating liver injury.
摘要
COVID-19 可导致严重的呼吸系统和多器官功能衰竭，包括肝损伤和转氨酶水平升高。本文探讨了 COVID-19 患者肝功能异常的潜在原因，以及针对 NPs 的管理方法，重点是预防和缓解肝损伤。
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3
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