Imam A, Karatas C, Imam R, Armutlu A, Mecit N, Karakaya A, Kalayoglu M, Kanmaz T
Liver Transplantation Department, Koc University Hospital, Istanbul, Turkey.
Pathology Department, Koc University Hospital, Istanbul, Turkey.
Int J Organ Transplant Med. 2020;11(4):202-206.
The effect of COVID-19 on the transplant recipients is not well-established. Many reports underestimate the effect of COVID-19 on the immunosuppressed population. Herein, we report on 3 pediatric liver transplant recipients who were transplanted at our center between February 11 and March 10, 2020-during the COVID-19 pandemic era. The 3 patients aged between 5 and 10 months, had a rapid and aggressive respiratory deterioration that necessitated mechanical ventilation and extracorporeal life support; and eventually died. The clinical and pathological pictures likely represent COVID-19 pneumonia. Chest x-rays showed progressive infiltrates. Lung autopsies showed diffuse alveolar damage in two cases. We concluded that COVID-19 is very likely to have catastrophic effects on transplant recipients.
新型冠状病毒肺炎（COVID-19）对移植受者的影响尚未完全明确。许多报告低估了COVID-19对免疫抑制人群的影响。在此，我们报告3例小儿肝移植受者，他们于2020年2月11日至3月10日在我们中心接受移植——处于COVID-19大流行时期。这3例患者年龄在5至10个月之间，出现了快速且严重的呼吸功能恶化，需要机械通气和体外生命支持；最终死亡。临床和病理表现可能代表COVID-19肺炎。胸部X光显示进行性浸润。两例肺尸检显示弥漫性肺泡损伤。我们得出结论，COVID-19很可能对移植受者产生灾难性影响。
