Shi Li, Wang Ying, Oppong Timothy Bonney, Fu Xiaoli, Yang Haiyan, Wang Yadong
Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Department of Social Medicine and Health Management, School of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Open Med (Wars). 2020 Apr 21;15(1):358-365. doi: 10.1515/med-2020-0403. eCollection 2020.
Sirtuin 6 (SIRT6) plays a critical role in the progression and development of gastrointestinal cancers. However, the association between SIRT6 expression and clinicopathological parameters and prognosis in gastrointestinal cancer patients remains inconclusive. Consequently, we conducted this meta-analysis to evaluate the importance of SIRT6 expression in various types of gastrointestinal cancers. PubMed, EMBASE, and Web of Science databases were systematically searched to screen the relevant literature. The reported or estimated hazard ratio (HR) and odds ratio (OR) and their corresponding 95% confidence interval (CI) were pooled to assess the strength of the association. Nine studies involving 867 patients were included in the meta-analysis. Overall analysis showed that high SIRT6 expression was related to better overall survival in gastrointestinal cancers (HR = 0.62, 95% CI = 0.47-0.82). High SIRT6 expression was also related to a favorable tumor node metastasis (TNM) stage (OR = 0.44, 95% CI = 0.28-0.70) among gastrointestinal cancer patients. Our meta-analysis revealed that high SIRT6 expression might be a potential biomarker predicting better prognosis in gastrointestinal cancers, which may offer options for gastrointestinal cancer treatment.
沉默调节蛋白6（SIRT6）在胃肠道癌症的进展和发展中起着关键作用。然而，SIRT6表达与胃肠道癌患者临床病理参数及预后之间的关联仍不明确。因此，我们进行了这项荟萃分析，以评估SIRT6表达在各类胃肠道癌症中的重要性。我们系统检索了PubMed、EMBASE和Web of Science数据库，以筛选相关文献。汇总报告的或估计的风险比（HR）和比值比（OR）及其相应的95%置信区间（CI），以评估关联强度。荟萃分析纳入了9项涉及867例患者的研究。总体分析表明，SIRT6高表达与胃肠道癌患者更好的总生存期相关（HR = 0.62，95%CI = 0.47 - 0.82）。SIRT6高表达还与胃肠道癌患者中良好的肿瘤淋巴结转移（TNM）分期相关（OR = 0.44，95%CI = 0.28 - 0.70）。我们的荟萃分析表明，SIRT6高表达可能是预测胃肠道癌预后较好的潜在生物标志物，这可能为胃肠道癌治疗提供选择。
