Konopka Magdalena J, Köhler Sebastian, Stehouwer Coen D A, Schaper Nicolaas C, Henry Ronald M A, van der Kallen Carla J H, Savelberg Hans H C M, Eussen Simone J P M, Dagniele Pieter C, van Dongen Martien C J M, Schram Miranda T, Koster Annemarie
Department of Social Medicine, Maastricht University, The Netherlands.
School for Public Health and Primary Care (CAPHRI), Maastricht University, The Netherlands.
Psychol Med. 2020 Dec 18;52(13):1-8. doi: 10.1017/S0033291720004924.
This study examined the associations between accelerometer-derived sedentary time (ST), lower intensity physical activity (LPA), higher intensity physical activity (HPA) and the incidence of depressive symptoms over 4 years of follow-up.
We included 2082 participants from The Maastricht Study (mean ± s.d. age 60.1 ± 8.0 years; 51.2% men) without depressive symptoms at baseline. ST, LPA and HPA were measured with the ActivPAL3 activity monitor. Depressive symptoms were measured annually over 4 years of follow-up with the 9-item Patient Health Questionnaire (PHQ-9). Cox regression analysis was performed to examine the associations between ST, LPA, HPA and incident depressive symptoms (PHQ-9 ⩾ 10). Analyses were adjusted for total waking time per day, age, sex, education level, type 2 diabetes mellitus, body mass index, total energy intake, smoking status and alcohol use.
During 7812.81 person-years of follow-up, 203 (9.8%) participants developed incident depressive symptoms. No significant associations [Hazard Ratio (95% confidence interval)] were found between sex-specific tertiles of ST (lowest v. highest tertile) [1.13 (0.76-1.66], or HPA (highest v. lowest tertile) [1.14 (0.78-1.69)] and incident depressive symptoms. LPA (highest v. lowest tertile) was statistically significantly associated with incident depressive symptoms in women [1.98 (1.19-3.29)], but not in men (p-interaction <0.01).
We did not observe an association between ST or HPA and incident depressive symptoms. Lower levels of daily LPA were associated with an increased risk of incident depressive symptoms in women. Future research is needed to investigate accelerometer-derived measured physical activity and ST with incident depressive symptoms, preferably stratified by sex.
本研究在4年的随访期间，探讨了通过加速度计测量得出的久坐时间（ST）、低强度身体活动（LPA）、高强度身体活动（HPA）与抑郁症状发生率之间的关联。
我们纳入了来自马斯特里赫特研究的2082名参与者（平均年龄±标准差为60.1±8.0岁；男性占51.2%），这些参与者在基线时无抑郁症状。使用ActivPAL3活动监测仪测量ST、LPA和HPA。在4年的随访期间，每年使用9项患者健康问卷（PHQ-9）测量抑郁症状。进行Cox回归分析，以检验ST、LPA、HPA与新发抑郁症状（PHQ-9⩾10）之间的关联。分析对每天的总清醒时间、年龄、性别、教育水平、2型糖尿病、体重指数、总能量摄入、吸烟状况和饮酒情况进行了校正。
在7812.81人年的随访期间，203名（9.8%）参与者出现了新发抑郁症状。在按性别划分的ST三分位数（最低三分位数与最高三分位数）[1.13（0.76 - 1.66）]或HPA三分位数（最高三分位数与最低三分位数）[1.14（0.78 - 1.69）]与新发抑郁症状之间，未发现显著关联。LPA（最高三分位数与最低三分位数）在女性中与新发抑郁症状有统计学显著关联[系数1.98（1.19 - 3.29）]，但在男性中无此关联（p交互作用<0.01）。
我们未观察到ST或HPA与新发抑郁症状之间存在关联。女性每日较低水平的LPA与新发抑郁症状风险增加有关。未来需要开展研究，以调查通过加速度计测量得出的身体活动和ST与新发抑郁症状之间的关系，最好按性别进行分层。
