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circadian 对卒中结局的影响——我们是否未能及时为神经保护而觉醒？

Circadian effects on stroke outcome - Did we not wake up in time for neuroprotection?

机构信息

School of Life Sciences, University of Warwick, Coventry, UK.

Faculty of Medicine, Institute of Medical Psychology, LMU Munich, Munich, Germany.

出版信息

J Cereb Blood Flow Metab. 2021 Mar;41(3):684-686. doi: 10.1177/0271678X20978711. Epub 2020 Dec 18.

DOI:10.1177/0271678X20978711
PMID:33337257
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7907996/
Abstract

The occurrence of stroke in humans peaks in the morning. A recent study revealed that time of day mitigates the therapeutic impact of neuroprotective paradigms. These findings might not only explain the previous failure of translation of neuroprotective therapies but inspire new paradigms in stroke chronopathophysiology research. Taking chronotype into account may complement the many factors that influence efficacy of experimental therapies in stroke.

摘要

人类中风的发生在早上达到高峰。最近的一项研究表明，一天中的时间会减轻神经保护模式的治疗效果。这些发现不仅可以解释以前神经保护疗法转化失败的原因，还可以为中风时间病理生理学研究中的新范式提供灵感。考虑到时间类型可能会补充影响中风实验疗法疗效的许多因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77d1/7922753/503da5f9eebe/10.1177_0271678X20978711-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77d1/7922753/503da5f9eebe/10.1177_0271678X20978711-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77d1/7922753/503da5f9eebe/10.1177_0271678X20978711-fig1.jpg

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Nature. 2020 Jun;582(7812):395-398. doi: 10.1038/s41586-020-2348-z. Epub 2020 Jun 3.
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Stem Cells as an Emerging Paradigm in Stroke 4: Advancing and Accelerating Preclinical Research.干细胞作为中风领域的新兴范例4：推进和加速临床前研究
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Large animals in neurointerventional research: A systematic review on models, techniques and their application in endovascular procedures for stroke, aneurysms and vascular malformations.
在晚上就诊的大血管闭塞（LVO）患者中观察到的高灌注强度比（HIR）。
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