Universidade do Estado do Amazonas, Programa de Pós-Graduação em Medicina Tropical, Manaus, AM, Brasil.
Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Instituto de Pesquisa Clínica Carlos Borborema, Manaus, AM, Brasil.
Rev Soc Bras Med Trop. 2020 Dec 21;54:e20200319. doi: 10.1590/0037-8682-0319-2021. eCollection 2020.
Bee venom is a natural toxin composed of several peptides. Massive envenoming causes severe local and systemic reactions. We report two cases of severe bee envenomation, of which one was fatal. We also describe clinical characteristics and immune markers. Both victims suffered from respiratory distress, renal failure, rhabdomyolysis, and shock. They required invasive mechanical ventilation, vasoactive drugs, and renal replacement therapy. Moreover, serum levels of chemokines, cytokines, and cell-free circulating nucleic acids demonstrated an intense inflammatory process. Massive envenoming produced systemic injury in the victims, with an uncontrolled inflammatory response, and a more significant chemotactic response in the fatal case.
蜂毒是一种由多种肽组成的天然毒素。大量蜂蜇会引起严重的局部和全身反应。我们报告了两例严重的蜂蜇伤病例，其中一例死亡。我们还描述了临床特征和免疫标志物。两名受害者均有呼吸窘迫、肾衰竭、横纹肌溶解和休克。他们需要有创机械通气、血管活性药物和肾脏替代治疗。此外，趋化因子、细胞因子和无细胞循环核酸的血清水平表明存在强烈的炎症过程。大量蜂蜇导致受害者全身损伤，炎症反应失控，致命病例的趋化反应更明显。
