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NIH 3T3成纤维细胞对15×(Ti/Zr)/Si多层系统上激光诱导周期性表面结构的响应。

Response of NIH 3T3 Fibroblast Cells on Laser-Induced Periodic Surface Structures on a 15×(Ti/Zr)/Si Multilayer System.

作者信息

Petrović Suzana, Peruško Davor, Mimidis Alexandros, Kavatzikidou Paraskeva, Kovač Janez, Ranella Anthi, Novaković Mirjana, Popović Maja, Stratakis Emmanuel

机构信息

Department of Atomic Physics, "VINČA" Institute of Nuclear Sciences-National Institute of the Republic of Serbia, University of Belgrade, P.O. Box 522, 11001 Belgrade, Serbia.

Institute of Electronic Structure and Laser (IESL), Foundation for Research and Technology (FORTH), N. Plastira 100, Vassilika Vouton, 70013 Heraklion, Greece.

出版信息

Nanomaterials (Basel). 2020 Dec 16;10(12):2531. doi: 10.3390/nano10122531.

DOI:10.3390/nano10122531
PMID:33339399
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7767124/
Abstract

Ultrafast laser processing with the formation of periodic surface nanostructures on the 15×(Ti/Zr)/Si multilayers is studied in order to the improve cell response. A novel nanocomposite structure in the form of 15x(Ti/Zr)/Si multilayer thin films, with satisfying mechanical properties and moderate biocompatibility, was deposited by ion sputtering on an Si substrate. The multilayer 15×(Ti/Zr)/Si thin films were modified by femtosecond laser pulses in air to induce the following modifications: (i) mixing of components inside of the multilayer structures, (ii) the formation of an ultrathin oxide layer at the surfaces, and (iii) surface nano-texturing with the creation of laser-induced periodic surface structure (LIPSS). The focus of this study was an examination of the novel Ti/Zr multilayer thin films in order to create a surface texture with suitable composition and structure for cell integration. Using the SEM and confocal microscopies of the laser-modified Ti/Zr surfaces with seeded cell culture (NIH 3T3 fibroblasts), it was found that cell adhesion and growth depend on the surface composition and morphological patterns. These results indicated a good proliferation of cells after two and four days with some tendency of the cell orientation along the LIPSSs.

摘要

为了改善细胞反应，研究了在15×(Ti/Zr)/Si多层膜上形成周期性表面纳米结构的超快激光加工。通过离子溅射在硅衬底上沉积了一种具有良好机械性能和适度生物相容性的新型15x(Ti/Zr)/Si多层薄膜纳米复合结构。在空气中用飞秒激光脉冲对多层15×(Ti/Zr)/Si薄膜进行改性，以诱导以下变化：(i)多层结构内部成分的混合；(ii)表面形成超薄氧化层；(iii)通过产生激光诱导周期性表面结构（LIPSS）进行表面纳米纹理化。本研究的重点是研究新型Ti/Zr多层薄膜，以创建具有适合细胞整合的成分和结构的表面纹理。通过对接种细胞培养（NIH 3T3成纤维细胞）的激光改性Ti/Zr表面进行扫描电子显微镜（SEM）和共聚焦显微镜观察，发现细胞粘附和生长取决于表面成分和形态模式。这些结果表明，细胞在两天和四天后有良好的增殖，并且有一些细胞沿LIPSSs方向排列的趋势。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/305e/7767124/732ec21f3e09/nanomaterials-10-02531-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/305e/7767124/5127b9e83c58/nanomaterials-10-02531-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/305e/7767124/4526d114278c/nanomaterials-10-02531-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/305e/7767124/ca808155bf61/nanomaterials-10-02531-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/305e/7767124/6c0a7240d101/nanomaterials-10-02531-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/305e/7767124/2e9f4e6fb6c1/nanomaterials-10-02531-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/305e/7767124/e3f31a08bdb8/nanomaterials-10-02531-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/305e/7767124/af7fee112518/nanomaterials-10-02531-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/305e/7767124/7474d2eeeac5/nanomaterials-10-02531-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/305e/7767124/732ec21f3e09/nanomaterials-10-02531-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/305e/7767124/5127b9e83c58/nanomaterials-10-02531-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/305e/7767124/4526d114278c/nanomaterials-10-02531-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/305e/7767124/ca808155bf61/nanomaterials-10-02531-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/305e/7767124/6c0a7240d101/nanomaterials-10-02531-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/305e/7767124/2e9f4e6fb6c1/nanomaterials-10-02531-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/305e/7767124/e3f31a08bdb8/nanomaterials-10-02531-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/305e/7767124/af7fee112518/nanomaterials-10-02531-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/305e/7767124/7474d2eeeac5/nanomaterials-10-02531-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/305e/7767124/732ec21f3e09/nanomaterials-10-02531-g009.jpg

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