Department of Thyroid, Breast Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
Molecules. 2020 Dec 16;25(24):5971. doi: 10.3390/molecules25245971.
The conventional view of using medicines as routine treatment of an intractable disease is being challenged in the face of extensive and growing evidence that flavonoids in foods, especially proanthocyanidins (PAs), can participate in tackling fatal diseases like cancer, cardiovascular and lipid metabolic diseases, both as a precautionary measure or as a dietary treatment. Although medical treatment with medicines will remain necessary in some cases, at least in the short term, PAs' function as antioxidant, anti-inflammatory drugs, signal pathway regulators remain critical in many diseases. This review article demonstrates the physical and biological properties of PAs, summarizes the health benefits of PAs found by researchers previously, and shows the possibility and importance of being a dietary treatment substance.
传统观点认为，使用药物作为一种棘手疾病的常规治疗方法，但面对越来越多的证据表明，食物中的类黄酮，尤其是原花青素（PAs），可以作为一种预防措施或饮食治疗方法，参与治疗癌症、心血管和脂质代谢疾病等致命疾病。虽然在某些情况下，至少在短期内，药物治疗仍将是必要的，但 PAs 的抗氧化剂、抗炎药物、信号通路调节剂的功能在许多疾病中仍然至关重要。本文综述了 PAs 的物理和生物学特性，总结了研究人员以前发现的 PAs 的健康益处，并展示了作为一种饮食治疗物质的可能性和重要性。
