Indurkar Abhishek, Pandit Ashish, Jain Ratnesh, Dandekar Prajakta
Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai, India.
Department of Chemical Engineering, Institute of Chemical Technology, Mumbai, India.
J Biomater Appl. 2021 Jul;36(1):76-94. doi: 10.1177/0885328220979273. Epub 2020 Dec 20.
Utility of plant-based materials in tissue engineering has exponentially increased over the years. Recent efforts in this area have been focused on substituting synthetic cross-linkers with natural ones derived from biological sources. These cross-linkers are essentially derived from the vegetative components of plants therefore suitably categorised as 'green' and renewable materials. Utilization of plant based cross-linkers in scaffolds and hydrogels offers several advantages compared to the synthetic ones. Natural compounds, like ferulic acid and genipin, when incorporated into scaffolds can promote cellular proliferation and growth, by regulation of growth factors. They participate in crucial activities, thus providing impetus for cell growth, function, differentiation and angiogenesis. Several natural compounds inherently possess anti-microbial, antioxidant and anti-inflammatory effects, which enhance the inherent characteristics of the scaffolds. Versatility of natural cross-linkers can be exploited for diverse applications. Integrating such potent molecules can enable the scaffold to display relevant characteristics for each function. This review article focuses on the recent developments with plant based cross-linkers that are employed for scaffold synthesis and their applications, which may be explored to synthesize scaffolds suitable for diverse biomedical applications.
多年来，植物基材料在组织工程中的应用呈指数级增长。该领域最近的努力集中于用源自生物来源的天然交联剂替代合成交联剂。这些交联剂基本上来源于植物的营养成分，因此可适当地归类为“绿色”可再生材料。与合成交联剂相比，在支架和水凝胶中使用植物基交联剂具有几个优点。当天然化合物如阿魏酸和京尼平掺入支架中时，可通过调节生长因子来促进细胞增殖和生长。它们参与关键活动，从而为细胞生长、功能、分化和血管生成提供动力。几种天然化合物本身具有抗菌、抗氧化和抗炎作用，可增强支架的固有特性。天然交联剂的多功能性可用于多种应用。整合这些强效分子可使支架展现出适合每种功能的相关特性。这篇综述文章重点关注用于支架合成的植物基交联剂的最新进展及其应用，这些进展可用于探索合成适合多种生物医学应用的支架。
