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新生黏附研究的最新进展与展望

Recent Advances and Prospects in the Research of Nascent Adhesions.

作者信息

Henning Stumpf Bernd, Ambriović-Ristov Andreja, Radenovic Aleksandra, Smith Ana-Sunčana

机构信息

PULS Group, Institute for Theoretical Physics, Interdisciplinary Center for Nanostructured Films, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

Laboratory for Cell Biology and Signalling, Division of Molecular Biology, Ruđer Bošković Institute, Zagreb, Croatia.

出版信息

Front Physiol. 2020 Dec 4;11:574371. doi: 10.3389/fphys.2020.574371. eCollection 2020.

DOI:10.3389/fphys.2020.574371
PMID:33343382
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7746844/
Abstract

Nascent adhesions are submicron transient structures promoting the early adhesion of cells to the extracellular matrix. Nascent adhesions typically consist of several tens of integrins, and serve as platforms for the recruitment and activation of proteins to build mature focal adhesions. They are also associated with early stage signaling and the mechanoresponse. Despite their crucial role in sampling the local extracellular matrix, very little is known about the mechanism of their formation. Consequently, there is a strong scientific activity focused on elucidating the physical and biochemical foundation of their development and function. Precisely the results of this effort will be summarized in this article.

摘要

新生黏附是亚微米级的瞬时结构，可促进细胞与细胞外基质的早期黏附。新生黏附通常由几十种整合素组成，并作为募集和激活蛋白质以构建成熟黏着斑的平台。它们还与早期信号传导和机械反应有关。尽管它们在采样局部细胞外基质中起着关键作用，但对其形成机制却知之甚少。因此，有大量的科学研究致力于阐明其发育和功能的物理和生化基础。本文将总结这一研究成果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99ef/7746844/7b823f25df35/fphys-11-574371-g0006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99ef/7746844/f476c96d7357/fphys-11-574371-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99ef/7746844/7b823f25df35/fphys-11-574371-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99ef/7746844/dce141db3dbd/fphys-11-574371-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99ef/7746844/3043f22dc80d/fphys-11-574371-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99ef/7746844/dc53ce7e75c2/fphys-11-574371-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99ef/7746844/d5ed0a98adbe/fphys-11-574371-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99ef/7746844/f476c96d7357/fphys-11-574371-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99ef/7746844/7b823f25df35/fphys-11-574371-g0006.jpg

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Nat Cell Biol. 2020 Aug;22(8):1011-1023. doi: 10.1038/s41556-020-0548-2. Epub 2020 Jul 27.
2
Integrin Crosstalk Contributes to the Complexity of Signalling and Unpredictable Cancer Cell Fates.整合素相互作用促成信号传导的复杂性和不可预测的癌细胞命运。
Cancers (Basel). 2020 Jul 15;12(7):1910. doi: 10.3390/cancers12071910.
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Regulation and dynamics of force transmission at individual cell-matrix adhesion bonds.
转化生长因子-β1通过整合素介导的机械性正反馈自动调节促进间充质干细胞的成骨作用。
iScience. 2024 Jun 12;27(7):110262. doi: 10.1016/j.isci.2024.110262. eCollection 2024 Jul 19.
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