Ghafouri-Fard Soudeh, Atarbashi-Moghadam Saede, Taheri Mohammad
Dental Research Center, Research Institute for Dental Sciences, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Oral and Maxillofacial Pathology, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Gene. 2021 Mar 1;771:145369. doi: 10.1016/j.gene.2020.145369. Epub 2020 Dec 17.
Ameloblastoma (AB), dentigerous cyst (DC) and Odontogenic keratocyst (OKC) are odontogenic lesions with propensity to malignant transformation or local invasion. The molecular mechanisms of development of these lesions are not fully understood. However, some researches have reported dysregulation of tumor suppressor genes or oncogenes in these lesions. Down-regulation of P53 gene has been reported in AB, DC and OKC. Moreover, several long non-coding RNAs such as ENST00000512916 and KIAA0125 have been dysregulated in AB tissues. Single nucleotide polymorphisms within a variety of genes have been associated with certain types of odontogenic lesions. In the current review, we summarize the current data about the expression pattern of genes in these lesions and the observed association between genetic polymorphisms and development of these lesions.
成釉细胞瘤（AB）、含牙囊肿（DC）和牙源性角化囊肿（OKC）是具有恶变或局部侵袭倾向的牙源性病变。这些病变的发生发展分子机制尚未完全明确。然而，一些研究报道了这些病变中肿瘤抑制基因或原癌基因的失调。在AB、DC和OKC中均有P53基因下调的报道。此外，在AB组织中，一些长链非编码RNA如ENST00000512916和KIAA0125表达失调。多种基因内的单核苷酸多态性与某些类型的牙源性病变相关。在本综述中，我们总结了关于这些病变中基因表达模式的现有数据，以及观察到的基因多态性与这些病变发生发展之间的关联。
