Filin Ivan Y, Solovyeva Valeriya V, Kitaeva Kristina V, Rutland Catrin S, Rizvanov Albert A
Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.
Faculty of Medicine and Health Science, University of Nottingham, Nottingham NG7 2QL, UK.
Biomedicines. 2020 Dec 17;8(12):621. doi: 10.3390/biomedicines8120621.
The search for an effective drug to treat oncological diseases, which have become the main scourge of mankind, has generated a lot of methods for studying this affliction. It has also become a serious challenge for scientists and clinicians who have needed to invent new ways of overcoming the problems encountered during treatments, and have also made important discoveries pertaining to fundamental issues relating to the emergence and development of malignant neoplasms. Understanding the basics of the human immune system interactions with tumor cells has enabled new cancer immunotherapy strategies. The initial successes observed in immunotherapy led to new methods of treating cancer and attracted the attention of the scientific and clinical communities due to the prospects of these methods. Nevertheless, there are still many problems that prevent immunotherapy from calling itself an effective drug in the fight against malignant neoplasms. This review examines the current state of affairs for each immunotherapy method, the effectiveness of the strategies under study, as well as possible ways to overcome the problems that have arisen and increase their therapeutic potentials.
寻找治疗肿瘤疾病的有效药物已成为人类面临的主要灾难,这催生了许多研究这种疾病的方法。对于科学家和临床医生来说,这也成为了一项严峻挑战,他们需要发明新方法来克服治疗过程中遇到的问题,并且在与恶性肿瘤的发生和发展相关的基本问题上也有了重要发现。了解人体免疫系统与肿瘤细胞相互作用的基础知识催生了新的癌症免疫治疗策略。免疫治疗初期取得的成功带来了新的癌症治疗方法,因其前景吸引了科学界和临床界的关注。然而,仍有许多问题阻碍免疫治疗成为对抗恶性肿瘤的有效药物。本综述探讨了每种免疫治疗方法的现状、所研究策略的有效性,以及克服出现的问题并提高其治疗潜力的可能途径。