García-Suárez Patricia C, Rentería Iván, Moncada-Jiménez José, Fry Andrew C, Jiménez-Maldonado Alberto
Facultad de Deportes Campus Ensenada, Universidad Autónoma de Baja California, Ensenada, México.
Human Movement Sciences Research Center, University of Costa Rica, San José, Costa Rica.
Dose Response. 2020 Dec 10;18(4):1559325820970818. doi: 10.1177/1559325820970818. eCollection 2020 Oct-Dec.
Acute bouts of intense exercise increase lactate concentration, which in turn stimulates brain-derived neurotrophic factor (BDNF) production. Cortisol released during intense exercise might inhibit BDNF synthesis. This study examined the acute effects of 2 protocols of strenuous exercise on serum BDNF. Seventeen physically-active healthy females (Age = 20.0 ± 0.9 yr., BMI = 23.0 ± 2.6 kg/m) performed a strenuous cycle-ergometer graded exercise test (GXT) and a high-intensity interval training session (HIIT). Serum BDNF, serum cortisol, cortisol: BDNF ratio and blood lactate (BLa) were recorded at baseline and immediately following exercise. Although non-statistically significant, the HIIT session elicited a higher magnitude of change from baseline for BDNF ( = 0.17) and cortisol ( = 1.18) than after the GXT ( = -0.26, and = 0.82, respectively). An interaction was found between GXT and HIIT trials and measurements on BLa levels, with higher post-exertion values after HIIT than after GXT (p < 0.0001, η = 0.650, 95%CI = 2.2, 5.2). The higher BLa levels did not raise circulating BDNF. The elevated cortisol levels may have overcome the effects of lactate on BDNF. However, the higher BLa induced by HIIT suggest that interval exercise modality on the long-term could be a feasible intervention to increase circulating peripheral BDNF, at least in untrained healthy women.
急性高强度运动可增加乳酸浓度，进而刺激脑源性神经营养因子（BDNF）的产生。高强度运动期间释放的皮质醇可能会抑制BDNF的合成。本研究考察了两种剧烈运动方案对血清BDNF的急性影响。17名身体活跃的健康女性（年龄=20.0±0.9岁，体重指数=23.0±2.6kg/m²）进行了剧烈的蹬车分级运动试验（GXT）和高强度间歇训练课程（HIIT）。在基线和运动后立即记录血清BDNF、血清皮质醇、皮质醇：BDNF比值和血乳酸（BLa）。尽管无统计学意义，但与GXT后相比（分别为=-0.26和=0.82），HIIT课程引起的BDNF（=0.17）和皮质醇（=1.18）相对于基线的变化幅度更大。在GXT和HIIT试验与BLa水平测量之间发现了交互作用，HIIT后的运动后值高于GXT后（p<0.0001，η=0.650，95%CI=2.2，5.2）。较高的BLa水平并未提高循环BDNF。升高的皮质醇水平可能抵消了乳酸对BDNF的影响。然而，HIIT诱导的较高BLa表明，至少在未经训练的健康女性中，长期的间歇运动方式可能是增加循环外周BDNF的一种可行干预措施。
