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本文引用的文献

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Malaria and COVID-19: commonalities, intersections and implications for sustaining malaria control.疟疾和 COVID-19:共同点、交汇点及其对维持疟疾控制的影响。
Pan Afr Med J. 2020 Sep 1;37(Suppl 1):1. doi: 10.11604/pamj.supp.2020.37.1.25738. eCollection 2020.
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Biological sex impacts COVID-19 outcomes.生物性别会影响新冠疫情的结果。
PLoS Pathog. 2020 Jun 22;16(6):e1008570. doi: 10.1371/journal.ppat.1008570. eCollection 2020 Jun.
3
Sex-specific clinical characteristics and prognosis of coronavirus disease-19 infection in Wuhan, China: A retrospective study of 168 severe patients.性别特异性临床特征和新型冠状病毒感染的预后:中国武汉 168 例重症患者的回顾性研究。
PLoS Pathog. 2020 Apr 28;16(4):e1008520. doi: 10.1371/journal.ppat.1008520. eCollection 2020 Apr.
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COVID-19 infection: Origin, transmission, and characteristics of human coronaviruses.新型冠状病毒肺炎感染:人类冠状病毒的起源、传播及特征
J Adv Res. 2020 Mar 16;24:91-98. doi: 10.1016/j.jare.2020.03.005. eCollection 2020 Jul.
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges.严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)和 2019 年冠状病毒病(COVID-19):疫情和挑战。
Int J Antimicrob Agents. 2020 Mar;55(3):105924. doi: 10.1016/j.ijantimicag.2020.105924. Epub 2020 Feb 17.
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Origin and evolution of pathogenic coronaviruses.致病冠状病毒的起源与演化。
Nat Rev Microbiol. 2019 Mar;17(3):181-192. doi: 10.1038/s41579-018-0118-9.
7
Evaluating Malaria Prevalence Using Clinical Diagnosis Compared with Microscopy and Rapid Diagnostic Tests in a Tertiary Healthcare Facility in Rivers State, Nigeria.在尼日利亚河流州的一家三级医疗机构中,使用临床诊断与显微镜检查和快速诊断测试相比较来评估疟疾流行情况。
J Trop Med. 2018 Apr 22;2018:3954717. doi: 10.1155/2018/3954717. eCollection 2018.
8
Sex-Based Differences in Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection.严重急性呼吸综合征冠状病毒感染易感性的性别差异
J Immunol. 2017 May 15;198(10):4046-4053. doi: 10.4049/jimmunol.1601896. Epub 2017 Apr 3.

性别在尼日利亚河流州疟疾与新冠病毒合并感染及一些相关因素中的作用

The Role of Sex in Malaria-COVID19 Coinfection and Some Associated Factors in Rivers State, Nigeria.

作者信息

Onosakponome E O, Wogu M N

机构信息

Department of Medical Laboratory Science, PAMO University of Medical Sciences, Port Harcourt, Nigeria.

Department of Animal and Environmental Biology, University of Port Harcourt, Nigeria.

出版信息

J Parasitol Res. 2020 Dec 2;2020:8829848. doi: 10.1155/2020/8829848. eCollection 2020.

DOI:10.1155/2020/8829848
PMID:33354370
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7737434/
Abstract

OBJECTIVES

Data on the coinfection of malaria and COVID-19 is highly limited especially in Africa due to the novel nature of the pandemic COVID-19. Malaria and COVID-19 share striking similarities in their symptoms. A cross-sectional randomized study was conducted to investigate the role of sex in the coinfection of malaria and COVID-19 as well as some associated factors in Rivers State, Nigeria.

METHODS

Ethical approval was obtained from the Rivers State Health and Ethics Committee before the commencement of this study, and the study was conducted at the COVID-19 Treatment Center Medical Laboratory, Rivers State, Nigeria. Intravenous blood samples from three hundred randomly selected consenting study participants were examined for species using Giemsa microscopy, while pretested questionnaires were used to obtain data on sex, risk factors, and symptoms. All data generated were analyzed statistically using the Chi-square test with a < 0.05 value considered significant.

RESULTS

All study participants had species (100% prevalence) with varying parasite loads, and . was the only species observed. Study participants (irrespective of sex) with low and high parasitaemia had the highest and least prevalence, respectively ( > 0.05). Male study participants experienced more symptoms than females ( > 0.05) except for sore throat which had an equal value among males and females. Travel history was the only risk factor that showed significant association with sex, and males had a higher value than females ( < 0.05).

CONCLUSION

Malaria and COVID-19 are major public health issues in Nigeria; more researches on these diseases especially in epidemiology, pathology, diagnosis, treatment, and vaccine production are vital.

摘要

目的

由于新型冠状病毒肺炎(COVID-19)大流行的特殊性,疟疾与COVID-19合并感染的数据非常有限,尤其是在非洲。疟疾和COVID-19在症状上有显著相似之处。在尼日利亚河流州开展了一项横断面随机研究,以调查性别在疟疾与COVID-19合并感染中的作用以及一些相关因素。

方法

在本研究开始前获得了河流州卫生与伦理委员会的伦理批准,研究在尼日利亚河流州COVID-19治疗中心医学实验室进行。使用吉姆萨显微镜对300名随机选择的同意参与研究的参与者的静脉血样本进行疟原虫种类检测,同时使用预先测试的问卷获取关于性别、危险因素和症状的数据。所有生成的数据均使用卡方检验进行统计分析,P<0.05被认为具有统计学意义。

结果

所有研究参与者均感染疟原虫(感染率100%),寄生虫载量各不相同,且仅观察到间日疟原虫。疟原虫血症水平低和高的研究参与者(无论性别)分别具有最高和最低的感染率(P>0.05)。男性研究参与者比女性经历更多症状(P>0.05),但喉咙痛在男性和女性中的发生率相同。旅行史是唯一与性别有显著关联的危险因素,男性的发生率高于女性(P<0.05)。

结论

疟疾和COVID-19是尼日利亚的主要公共卫生问题;对这些疾病尤其是在流行病学、病理学、诊断、治疗和疫苗生产方面进行更多研究至关重要。