Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.
Division of Plastic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Sci Adv. 2020 Dec 18;6(51). doi: 10.1126/sciadv.abd1061. Print 2020 Dec.
Flaps are common in plastic surgery to reconstruct large tissue defects in cases such as trauma or cancer. However, most tissue oximeters used for monitoring ischemia in postoperative flaps are bulky, wired devices, which hinder direct flap observation. Here, we present the results of a clinical trial using a previously untried paintable transparent phosphorescent bandage to assess the tissue's partial pressure of oxygen (pO). Statistical analysis revealed a strong relationship ( < 0.0001) between the rates of change of tissue oxygenation measured by the bandage and blood oxygen saturation (%stO) readings from a standard-of-care ViOptix near-infrared spectroscopy oximeter. In addition, the oxygen-sensing bandage showed no adverse effects, proved easy handling, and yielded bright images across all skin tones with a digital single-lens reflex (DSLR) camera. This demonstrates the feasibility of using phosphorescent materials to monitor flaps postoperatively and lays the groundwork for future exploration in other tissue oxygen sensing applications.
皮瓣在整形手术中很常见，用于重建创伤或癌症等情况下的大面积组织缺损。然而，大多数用于监测术后皮瓣缺血的组织血氧计都是体积庞大、有线的设备，这阻碍了对皮瓣的直接观察。在这里，我们介绍了一项使用以前未经尝试的可涂漆透明磷光绷带评估组织氧分压 (pO) 的临床试验结果。统计分析显示，绷带测量的组织氧合变化率与标准护理 ViOptix 近红外光谱血氧计的血氧饱和度 (%stO) 读数之间存在很强的相关性（<0.0001）。此外，氧敏绷带没有不良影响，易于操作，并且使用数码单反相机 (DSLR) 可以在所有肤色上获得明亮的图像。这证明了使用磷光材料在手术后监测皮瓣的可行性，并为未来在其他组织氧传感应用中的探索奠定了基础。
