Ohlsén L, Englesson S
Br J Anaesth. 1980 Apr;52(4):413-7. doi: 10.1093/bja/52.4.413.
Ane-Pad (A 2358, Astra Lakemedel AB), a new local anesthetic formulation for application to the skin has been tested in the removal of split skin grafts. Ane-Pad is a thin cotton pad, containing a solution of 10% ketocaine base in a solvent mixture of isopropanol, glycerol and water. The pad has been used on the donor sites of 173 patients with a minimum application time of 1 h before surgery. Eighteen patients complained of slight, transient irritation immediately after application. After removal of the pad erythema was present in 39 patients and oedema in eight. In 157 patients (90.8%) analgesia was adequate. Two patients (1.1%) needed additional anaesthesia. The concentration of ketocaine in the blood was measured in 101 patients and did not exceed 850 ng ml--1. Therewere no systemic side-effects.
Ane-Pad（A 2358，阿斯特拉制药公司）是一种用于皮肤的新型局部麻醉制剂，已在取皮片移植手术中进行了测试。Ane-Pad是一种薄棉垫，含有10%酮卡因碱在异丙醇、甘油和水的混合溶剂中的溶液。该棉垫已用于173例患者的供皮区，术前最少使用时间为1小时。18例患者在使用后立即抱怨有轻微、短暂的刺激。取下棉垫后，39例患者出现红斑，8例出现水肿。157例患者（90.8%）镇痛效果良好。2例患者（1.1%）需要额外麻醉。对101例患者进行了血液中酮卡因浓度的测量，浓度不超过850 ng/ml-1。未出现全身性副作用。
