Faculty of Human Development, Kokugakuin University, Yokohama, Kanagawa, Japan.
Department of Sport Social Management, Kibi International University, Takahashi, Okayama, Japan.
J Appl Physiol (1985). 2021 Mar 1;130(3):827-835. doi: 10.1152/japplphysiol.00651.2020. Epub 2020 Dec 24.
Central arterial compliance decreases drastically after menopause. Regular intake of soy isoflavone and aerobic exercise increase arterial compliance. The equol is a metabolite of isoflavone daidzein by gut microbiome. We determined whether the equol-producing status affects aerobic exercise-induced improvement in carotid arterial compliance. Forty-three postmenopausal women were assigned to two intervention groups: ) exercise and isoflavone (Ex+Iso, = 27 females) or ) isoflavone interventions (Iso; = 16 females). Participants of the Ex+Iso intervention group completed an 8-wk aerobic exercise training, and all participants were administered with oral isoflavone supplements during the interventions. The equol-producing status (equol producers or nonproducers) was determined from urine equol concentrations after a soy challenge. In the Ex+Iso intervention group, carotid arterial compliance increased in the equol producers (0.084 ± 0.030→0.117 ± 0.035 mm/mmHg), but not in the nonproducers (0.089 ± 0.028→0.097 ± 0.026 mm/mmHg) after the intervention (interaction effect; < 0.05). The magnitude of increases in carotid arterial compliance was significantly greater in the equol producers than in the non-equol producers ( < 0.05). In the isoflavone intervention group, there were no changes in any parameters after the intervention irrespective of the equol status. These results suggest that equol-producing status is obligatory to aerobic exercise training-induced improvements in central arterial compliance in postmenopausal women. Isoflavone intake and aerobic exercise increase central artery compliance. Equol, a metabolite of isoflavone daidzein by gut microbiome, has beneficial effects on vascular function. We demonstrated for the first time that the interaction of aerobic exercise and equol production status plays an essential role in improvements in central artery compliance in postmenopausal women. More specifically, the equol-producing status was obligatory to exercise training-induced improvements in central arterial compliance in postmenopausal women.
绝经后，动脉顺应性会大幅下降。经常摄入大豆异黄酮和进行有氧运动可以增加动脉顺应性。肠内微生物将大豆异黄酮中的大豆苷元代谢为黄豆苷元。我们旨在确定黄豆苷元产生状态是否会影响有氧运动对颈动脉顺应性的改善作用。43 名绝经后妇女被分为两组：）运动和异黄酮（Ex+Iso，n=27 名女性）或）异黄酮干预（Iso；n=16 名女性）。Ex+Iso 干预组的参与者完成了 8 周的有氧运动训练，并且在干预期间所有参与者都接受了口服异黄酮补充剂。通过大豆挑战后尿液中黄豆苷元浓度确定黄豆苷元产生状态（黄豆苷元产生者或非产生者）。在 Ex+Iso 干预组中，在黄豆苷元产生者中，颈动脉顺应性增加（0.084 ± 0.030→0.117 ± 0.035 mm/mmHg），但在非产生者中没有增加（0.089 ± 0.028→0.097 ± 0.026 mm/mmHg）（交互作用效应； < 0.05）。与非黄豆苷元产生者相比，黄豆苷元产生者颈动脉顺应性的增加幅度明显更大（ < 0.05）。在异黄酮干预组中，无论黄豆苷元状态如何，干预后所有参数均无变化。这些结果表明，在绝经后妇女中，黄豆苷元产生状态是有氧运动训练引起的中心动脉顺应性改善所必需的。异黄酮摄入和有氧运动可增加中心动脉顺应性。肠内微生物将大豆异黄酮中的大豆苷元代谢为黄豆苷元，对血管功能有有益作用。我们首次证明，有氧运动和黄豆苷元产生状态的相互作用在绝经后妇女中心动脉顺应性的改善中起着至关重要的作用。具体来说，黄豆苷元产生状态是绝经后妇女运动训练引起的中心动脉顺应性改善所必需的。
