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The Sinus Node: Still Mysterious After All These Years.

作者信息

Weiss James N, Qu Zhilin

机构信息

Departments of Medicine (Cardiology), Physiology and Biomathematics, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.

Departments of Medicine (Cardiology), Physiology and Biomathematics, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.

出版信息

JACC Clin Electrophysiol. 2020 Dec;6(14):1841-1843. doi: 10.1016/j.jacep.2020.09.017. Epub 2020 Nov 25.

DOI:10.1016/j.jacep.2020.09.017
PMID:33357581
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11316444/
Abstract
摘要

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Evidence of Superior and Inferior Sinoatrial Nodes in the Mammalian Heart.哺乳动物心脏中窦房结优势和劣势的证据。
JACC Clin Electrophysiol. 2020 Dec;6(14):1827-1840. doi: 10.1016/j.jacep.2020.09.012. Epub 2020 Nov 25.
2
Synchronized Cardiac Impulses Emerge From Heterogeneous Local Calcium Signals Within and Among Cells of Pacemaker Tissue.起搏组织细胞内和细胞间的异质局部钙信号中出现同步心脏冲动。
JACC Clin Electrophysiol. 2020 Aug;6(8):907-931. doi: 10.1016/j.jacep.2020.06.022.
3
Positive Feedback Mechanisms among Local Ca Releases, NCX, and I Ignite Pacemaker Action Potentials.
通阳活血颗粒对窦房结细胞缺氧/复氧损伤时触发期的电生理效应。
Front Physiol. 2024 Jun 7;15:1402478. doi: 10.3389/fphys.2024.1402478. eCollection 2024.
4
A novel conceptual model of heart rate autonomic modulation based on a small-world modular structure of the sinoatrial node.基于窦房结小世界模块化结构的心率自主调节新的概念模型。
Front Physiol. 2023 Dec 11;14:1276023. doi: 10.3389/fphys.2023.1276023. eCollection 2023.
5
The method of sinus node-like pacemaker cells from human induced pluripotent stem cells by BMP and Wnt signaling.通过 BMP 和 Wnt 信号从人诱导多能干细胞中获得窦房结样起搏细胞的方法。
Cell Biol Toxicol. 2023 Dec;39(6):2725-2741. doi: 10.1007/s10565-023-09797-7. Epub 2023 Mar 1.
6
The paradigm shift: Heartbeat initiation without "the pacemaker cell".范式转变：无“起搏细胞”的心跳起始
Front Physiol. 2022 Dec 9;13:1090162. doi: 10.3389/fphys.2022.1090162. eCollection 2022.
7
Sinus node dysfunction: current understanding and future directions.窦房结功能障碍：当前的认识和未来的方向。
Am J Physiol Heart Circ Physiol. 2023 Mar 1;324(3):H259-H278. doi: 10.1152/ajpheart.00618.2022. Epub 2022 Dec 23.
8
Adenosine reduces sinoatrial node cell action potential firing rate by uncoupling its membrane and calcium clocks.腺苷通过解偶联其膜时钟和钙时钟来降低窦房结细胞动作电位的发放频率。
Front Physiol. 2022 Nov 24;13:977807. doi: 10.3389/fphys.2022.977807. eCollection 2022.
9
Novel Insights into the Sinoatrial Node in Single-Cell RNA Sequencing: From Developmental Biology to Physiological Function.单细胞RNA测序中对窦房结的新见解：从发育生物学到生理功能
J Cardiovasc Dev Dis. 2022 Nov 18;9(11):402. doi: 10.3390/jcdd9110402.
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Characterization of the pace-and-drive capacity of the human sinoatrial node: A 3D in silico study.人类窦房结起搏和驱动能力的特性：一项 3D 体内研究。
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局部钙释放、钠钙交换体（NCX）和I之间的正反馈机制引发起搏器动作电位。
Biophys J. 2018 Apr 24;114(8):2024. doi: 10.1016/j.bpj.2018.03.024.
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Mapping cardiac pacemaker circuits: methodological puzzles of the sinoatrial node optical mapping.心脏起搏器电路的映射：窦房结光学映射的方法学难题。
Circ Res. 2010 Feb 5;106(2):255-71. doi: 10.1161/CIRCRESAHA.109.209841.
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Intracellular calcium dynamics and acceleration of sinus rhythm by beta-adrenergic stimulation.细胞内钙动力学与β-肾上腺素能刺激对窦性心律的加速作用
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