体内声电成像技术用于高分辨率可视化心脏电时空动力学。
In vivo acoustoelectric imaging for high-resolution visualization of cardiac electric spatiotemporal dynamics.
出版信息
Appl Opt. 2020 Dec 20;59(36):11292-11300. doi: 10.1364/AO.410172.
Abstract
Acoustoelectric cardiac imaging (ACI) is a hybrid modality that exploits the interaction of an ultrasonic pressure wave and the resistivity of tissue to map current densities in the heart. This study demonstrates for the first time in vivo ACI in a swine model. ACI measured beat-to-beat variability (=20) of the peak of the cardiac activation wave at one location of the left ventricle as 5.32±0.74µ, 3.26±0.54 below the epicardial surface, and 2.67±0.56 before the peak of the local electrogram. Cross-sectional ACI images exhibited propagation velocities of 0.192±0.061/ along the epicardial-endocardial axis with an SNR of 24.9 dB. This study demonstrates beat-to-beat and multidimensional ACI, which might reveal important information to help guide electroanatomic mapping procedures during ablation therapy.
摘要
声电心脏成像是一种混合模式，利用超声压力波和组织电阻率的相互作用来绘制心脏内的电流密度图。本研究首次在猪模型中进行了体内声电心脏成像。声电心脏成像测量了左心室一个位置的心脏激活波峰值的逐搏变异性（=20），在心外膜表面下 5.32±0.74µ，在局部电图峰值前 2.67±0.56。横截面声电心脏成像显示传播速度为 0.192±0.061/，沿心外膜-心内膜轴，信噪比为 24.9dB。本研究证明了逐搏和多维声电心脏成像，这可能揭示重要信息，有助于指导消融治疗期间的电解剖标测程序。
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