Zhang Zhe, Bao Yang-Yang, Zhou Shui-Hong
Department of Otolaryngology, Peoples Hospital of Yuyao City, Yuyao 315400, Zhejiang, People's Republic of China.
Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, People's Republic of China.
Int J Gen Med. 2020 Dec 14;13:1509-1514. doi: 10.2147/IJGM.S284952. eCollection 2020.
The presence of extra-gastric H/K ATPases may explain the clinically significant effect of proton pump inhibitor (PPI) pharmacotherapy in patients with chronic laryngitis related to laryngopharyngeal reflux disease (LPRD) but without gastroesophageal reflux disease (GERD) symptoms. Given the need for a better understanding of GERD and LPRD, we review the various proton pumps with respect to their classification, function, and distribution. We then consider the potential role of the laryngeal H/K ATPase pump in LPRD.
We searched databases of PubMed, EMBASE, and Web of Science to achieve related published before September 15, 2020.
There were only seven English-literatures meeting inclusive criteria about laryngeal H/K ATPases. Some studies provide convincing evidence of a laryngeal H/K ATPase in normal laryngeal tissues but also suggest the potential role of the proton pump in the abnormal mucus secretion frequently seen in patients with chronic laryngitis.
A laryngeal H/K ATPase expresses in normal laryngeal tissues. These findings question the current understanding of GERD and LPRD.
胃外H⁺/K⁺ATP酶的存在可能解释了质子泵抑制剂（PPI）药物治疗对患有与喉咽反流病（LPRD）相关的慢性喉炎但无胃食管反流病（GERD）症状患者的临床显著疗效。鉴于需要更好地理解GERD和LPRD，我们就各种质子泵的分类、功能和分布进行综述。然后我们考虑喉H⁺/K⁺ATP酶泵在LPRD中的潜在作用。
我们检索了PubMed、EMBASE和科学网数据库，以获取2020年9月15日前发表的相关文献。
关于喉H⁺/K⁺ATP酶，仅有7篇英文文献符合纳入标准。一些研究提供了令人信服的证据，证明正常喉组织中存在喉H⁺/K⁺ATP酶，同时也表明质子泵在慢性喉炎患者常见的异常黏液分泌中具有潜在作用。
喉H⁺/K⁺ATP酶在正常喉组织中表达。这些发现对目前对GERD和LPRD的理解提出了质疑。
