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葡萄籽油对肉鸡血清代谢组和盲肠微生物菌群的影响

Change of Serum Metabolome and Cecal Microflora in Broiler Chickens Supplemented With Grape Seed Extracts.

机构信息

College of Standardization, China Jiliang University, Hangzhou, China.

Zhejiang Vegamax Biotechnology Co., Ltd., Anji, China.

出版信息

Front Immunol. 2020 Dec 8;11:610934. doi: 10.3389/fimmu.2020.610934. eCollection 2020.

DOI:10.3389/fimmu.2020.610934
PMID:33363546
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7753974/
Abstract

Grape seed is rich in vitamin E, flavonoids, and proanthocyanidins and has the potential to be used as an antibiotic substitute in broilers. We investigated the effects of grape seed proanthocyanidin extract (GSPE) on growth performance, immune responses, cecal microflora, and serum metabolism in early stage broilers. Data indicated that GSPE improved broiler growth performance by strengthening antioxidant capacity, enhancing immune responses, and increasing cecal short chain fatty acids. 16S rRNA sequencing indicated that GSPE changed the predominant cecal microflora and induced the metabolism of amino acids, lipids, and carbohydrates. An UPLC-Q-TOF/MS-based metabolomics analysis identified 23 serum metabolites (mainly related to lipid, amino acid, and alkaloid) were extremely changed by GSPE treatment. The correlations between the changes of cecal microflora and serum metabolites in birds fed with GSPE were analyzed. Hence, GSPE potentially provides active ingredients that may be used as antibiotic substitute and reduces environmental pollution by grape by-products.

摘要

葡萄籽富含维生素 E、类黄酮和原花青素，有潜力作为肉鸡中的抗生素替代品。我们研究了葡萄籽原花青素提取物（GSPE）对早期肉鸡生长性能、免疫反应、盲肠微生物群和血清代谢的影响。数据表明，GSPE 通过增强抗氧化能力、增强免疫反应和增加盲肠短链脂肪酸来改善肉鸡的生长性能。16S rRNA 测序表明，GSPE 改变了主要的盲肠微生物群，并诱导了氨基酸、脂质和碳水化合物的代谢。基于 UPLC-Q-TOF/MS 的代谢组学分析鉴定出 23 种血清代谢物（主要与脂质、氨基酸和生物碱有关）被 GSPE 处理极大地改变。分析了饲喂 GSPE 的鸟类盲肠微生物群和血清代谢物变化之间的相关性。因此，GSPE 可能为抗生素替代品提供了活性成分，并减少了葡萄副产品对环境的污染。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8fc/7753974/d0746e676caa/fimmu-11-610934-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8fc/7753974/ab7c16d004e2/fimmu-11-610934-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8fc/7753974/2c3fb3e34046/fimmu-11-610934-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8fc/7753974/7451d05abd80/fimmu-11-610934-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8fc/7753974/0049b11dc098/fimmu-11-610934-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8fc/7753974/5e6e884c086a/fimmu-11-610934-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8fc/7753974/6f4502903dca/fimmu-11-610934-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8fc/7753974/d0746e676caa/fimmu-11-610934-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8fc/7753974/ab7c16d004e2/fimmu-11-610934-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8fc/7753974/2c3fb3e34046/fimmu-11-610934-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8fc/7753974/7451d05abd80/fimmu-11-610934-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8fc/7753974/0049b11dc098/fimmu-11-610934-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8fc/7753974/5e6e884c086a/fimmu-11-610934-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8fc/7753974/6f4502903dca/fimmu-11-610934-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8fc/7753974/d0746e676caa/fimmu-11-610934-g007.jpg

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