Eder Klaus, Ringseis Robert, Gessner Denise K
Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig Universität Giessen, Heinrich-Buff-Ring 26-32, 35392 Giessen, Germany.
Center of Sustainable Food Systems, Justus Liebig Universität Giessen, Senkenbergstrasse 3, 35390 Giessen, Germany.
Animals (Basel). 2025 May 23;15(11):1536. doi: 10.3390/ani15111536.
High-yielding farm animals often face severe metabolic stress, compounded by environmental stressors such as psychosocial stress, heat stress, intensive housing systems, and poor hygiene management. These factors result in oxidative stress and inflammatory processes, which adversely affect both animal health and performance. Polyphenols are known to alleviate both oxidative stress and inflammatory responses. Since grapes are rich in polyphenols, by-products of winemaking could have beneficial effects on these processes. This review aims to provide an overview of the potential antioxidative and anti-inflammatory effects of grape by-products in farm animals. The first section of the review examines the causes and consequences of oxidative stress and inflammation. The second section highlights the general effects of polyphenols in addressing these issues. The third and central part of the review presents an overview of findings from studies investigating the impact of various grape-derived polyphenols on the antioxidant system and inflammation in pigs, chicken, and cattle. Overall, these studies demonstrate that grape by-products can effectively reduce oxidative stress and inflammation in pigs and chickens, often leading to improved performance. In cattle, however, fewer studies have been conducted, and the results regarding oxidative stress and inflammation are less consistent. In conclusion, grape by-products represent valuable feed options for preventing oxidative stress and inflammation in monogastric farm animals (pigs, chickens).
高产农场动物常常面临严重的代谢应激，心理社会应激、热应激、集约化养殖系统和不良卫生管理等环境应激源又使其雪上加霜。这些因素会导致氧化应激和炎症反应，对动物健康和生产性能产生不利影响。众所周知，多酚类物质可以减轻氧化应激和炎症反应。由于葡萄富含多酚，酿酒副产品可能对这些过程具有有益作用。本综述旨在概述葡萄副产品对农场动物潜在的抗氧化和抗炎作用。综述的第一部分探讨氧化应激和炎症的成因及后果。第二部分重点介绍多酚类物质在解决这些问题方面的总体作用。综述的第三部分也是核心部分，概述了各项研究的结果，这些研究调查了各种葡萄衍生多酚对猪、鸡和牛的抗氧化系统及炎症的影响。总体而言，这些研究表明，葡萄副产品可以有效减轻猪和鸡的氧化应激和炎症，常常能提高生产性能。然而，针对牛的研究较少，关于氧化应激和炎症的结果也不太一致。总之，葡萄副产品是预防单胃农场动物（猪、鸡）氧化应激和炎症的宝贵饲料选择。
