Nguyen Phu-Tho, Nguyen Tho-Thi, Bui Duc-Cuong, Hong Phuoc-Toan, Hoang Quoc-Khanh, Nguyen Huu-Thanh
Graduate University of Sciences and Technology, Vietnam Academy of Science and Technology, Ha Noi, Vietnam.
Department of Biotechnology, An Giang University, An Giang, Vietnam.
AIMS Microbiol. 2020 Nov 17;6(4):451-469. doi: 10.3934/microbiol.2020027. eCollection 2020.
Exopolysaccharides (EPSs) are biological polymers secreted by microorganisms including Lactic acid bacteria (LAB) to cope with harsh environmental conditions. EPSs are one of the main components involved in the formation of extracellular biofilm matrix to protect microorganisms from adverse factors such as temperature, pH, antibiotics, host immune defenses, etc.. In this review, we discuss EPS biosynthesis; the role of EPSs in LAB stress tolerance; the impact of environmental stresses on EPS production and on the expression of genes involved in EPS synthesis. The evaluation results indicated that environmental stresses can alter EPS biosynthesis in LAB. For further studies, environmental stresses may be used to generate a new EPS type with high biological activity for industrial applications.
胞外多糖（EPSs）是包括乳酸菌（LAB）在内的微生物分泌的生物聚合物，用于应对恶劣的环境条件。EPSs是参与细胞外生物膜基质形成的主要成分之一，可保护微生物免受温度、pH值、抗生素、宿主免疫防御等不利因素的影响。在本综述中，我们讨论了EPS的生物合成；EPSs在LAB应激耐受性中的作用；环境胁迫对EPS产生以及对参与EPS合成的基因表达的影响。评估结果表明，环境胁迫可以改变LAB中EPS的生物合成。为了进一步研究，可以利用环境胁迫来产生具有高生物活性的新型EPS用于工业应用。
