Natural Products Research Laboratory, Department of Biotechnology, School of Life Sciences, Pondicherry University, Puducherry, India.
J Food Biochem. 2021 Feb;45(2):e13595. doi: 10.1111/jfbc.13595. Epub 2020 Dec 23.
A sedentary lifestyle combined with the intake of high-calorie diet has been the paramount cause of metabolic syndrome (MS) which is now a serious concern of public health worldwide as it involves the coexistence of hypertension, hyperlipidemia, glucose intolerance, and obesity. Hence, identifying a suitable strategy to overcome the worldwide menace of MS is imperative. Macrotyloma uniflorum a lesser known legume is highly nutritious and notable for its ethano-medicinal potential. Herein, the influence of M. uniflorum in high-fat dietinduced metabolic changes in a rodent model of metabolic syndrome was evaluated. Serum levels of glucose, total cholesterol, triglycerides, VLDL-c, and bodyweight were decreased, whereas HDL-c was increased in M. uniflorum-treated MS rats. The protein expression (AMPK-α, PPAR-α, and PPAR-γ) and gene expression (leptin, adiponectin, resistin, UCP2, NF-κB, and IL-6) results are impressive to highlight that M. uniflorum modulates the pathological conditions of MS and proves to be cardioprotective. Furthermore, the histopathological analysis confirmed the pathological changes and substantiates the influence of M. uniflorum to overcome MS. The HPLC and GC (MS) profiling reveals the presence of an array of polyphenols such as rutin (694.61 μg/g), catechin (500.12 μg/g), epicatechin (158.10 μg/g), gallic acid (17.98 μg/g), ferulic acid (10.911 μg/g), daidzein (6.51 μg/g), and PUFA, respectively, which probably exhibits the therapeutic effect on MS and associated complications by modulating lipid metabolism and adipogenesis. PRACTICAL APPLICATIONS: Metabolic disorders like CVD and diabetes are leading cause of mortality and morbidity worldwide. With emerging issues on adverse effects of modern drugs, the emphasis on "Food is Medicine and Medicine as Food" has taken dramatic dimensions in the healthcare sector. Therefore, nutraceuticals are in great demand in the developed world off late. Legumes, are potent elements in a balanced diet next to cereals. Exploring the medicinal properties of legumes could bring a revolution in public health and nutraceutical industries. This study scientifically validated the phytochemicals in M. uniflorum for its functional potential in the management of Metabolic Syndrome (MS). This study would help the nutraceutical industries to develop functional foods using M. uniflorum seeds to make porridges and soups or nutraceutical supplements with the bioflavonoids isolated from M. uniflorum for the management of metabolic disorders by mitigating hyperlipidemia, oxidative stress, and inflammation.
一种久坐的生活方式加上高热量饮食是代谢综合征（MS）的主要原因，这是目前全球公共卫生的一个严重问题，因为它涉及高血压、高血脂、葡萄糖耐量受损和肥胖的共存。因此，确定一种合适的策略来克服全球 MS 的威胁是至关重要的。Macrotyloma uniflorum 是一种不太知名的豆类，它营养丰富，以其乙醇药用潜力而闻名。在此，评估了 M. uniflorum 在高脂肪饮食诱导的代谢综合征啮齿动物模型中代谢变化的影响。血清葡萄糖、总胆固醇、甘油三酯、VLDL-c 和体重降低，而高密度脂蛋白胆固醇升高。M. uniflorum 治疗 MS 大鼠的蛋白表达（AMPK-α、PPAR-α 和 PPAR-γ）和基因表达（瘦素、脂联素、抵抗素、UCP2、NF-κB 和 IL-6）结果令人印象深刻，表明 M. uniflorum 调节 MS 的病理状况，并被证明具有心脏保护作用。此外，组织病理学分析证实了病理变化，并证实了 M. uniflorum 克服 MS 的影响。HPLC 和 GC（MS）分析表明存在多种多酚，如芦丁（694.61μg/g）、儿茶素（500.12μg/g）、表儿茶素（158.10μg/g）、没食子酸（17.98μg/g）、阿魏酸（10.911μg/g）、大豆苷元（6.51μg/g）和多不饱和脂肪酸，这可能通过调节脂质代谢和脂肪生成对 MS 及其相关并发症发挥治疗作用。实际应用：心血管疾病和糖尿病等代谢紊乱是全球死亡率和发病率的主要原因。随着现代药物不良反应问题的出现，“食物即药物，药物即食物”的强调在医疗保健领域已经达到了一个戏剧性的维度。因此，最近在发达国家对营养保健品的需求很大。豆类是除谷物外均衡饮食的重要组成部分。探索豆类的药用特性可能会给公共卫生和营养保健品行业带来一场革命。这项研究从科学上验证了 M. uniflorum 的植物化学物质在代谢综合征（MS）管理中的功能潜力。这项研究将帮助营养保健品行业利用 M. uniflorum 种子开发功能性食品，如粥和汤，或利用 M. uniflorum 中分离的生物类黄酮作为营养保健品，通过减轻高血脂、氧化应激和炎症来管理代谢紊乱。
