吸烟与雄激素受体阳性乳腺癌。
Cigarettes smoking and androgen receptor-positive breast cancer.
机构信息
Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan.
Piedmont Cancer Registry, A.O.U, Citta` della Salute e della Scienza di Torino.
出版信息
Eur J Cancer Prev. 2021 Nov 1;30(6):469-471. doi: 10.1097/CEJ.0000000000000661.
OBJECTIVES
Cigarette smoking is related to higher levels of circulating androgens, but its association with androgen receptor (AR) status is still unaddressed.
METHODS
We analysed, with a case-only approach, smoking habits according to AR status in 112 cases of invasive female breast cancer, from the Piedmont Cancer Registry. We used a multivariate logistic regression model to estimate the odds ratio (OR) and the corresponding confidence interval (CI).
RESULTS
The OR of AR-positive breast cancer (versus AR-negative) for ever smokers (versus never) was 2.85 (95% CI 1.02-7.96).
CONCLUSION
Smoking is related to AR-positive breast cancer.
目的
吸烟与循环雄激素水平升高有关，但吸烟与雄激素受体（AR）状态的关系仍未得到解决。
方法
我们采用病例对照研究方法，分析了来自皮埃蒙特癌症登记处的 112 例浸润性女性乳腺癌患者的 AR 状态与吸烟习惯。我们使用多变量逻辑回归模型来估计比值比（OR）和相应的置信区间（CI）。
结果
与 AR 阴性乳腺癌相比，AR 阳性乳腺癌（与 AR 阴性相比）的吸烟者（与从不吸烟者相比）的 OR 为 2.85（95%CI 1.02-7.96）。
结论
吸烟与 AR 阳性乳腺癌有关。
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