Parra Dora Inés, Trapero Gimeno Isabel, Sánchez Rodríguez Javier Mauricio, Rodríguez Corredor Lizeth Catherine, Hernández Vargas Juliana Alexandra, López Romero Luis Alberto, García López Fernando J, Escudero-Gómez Cristina, Trujillo-Cáceres Silvia Juliana, Serrano-Gallardo Pilar, Vera-Cala Lina M
Nursing School, Universidad Industrial de Santander, Bucaramanga, Colombia
Clinical and Community Nursing Doctoral student, Universitat de València, Valencia, Spain.
BMJ Open. 2020 Dec 22;10(12):e037920. doi: 10.1136/bmjopen-2020-037920.
Hypertension is a chronic disease with 31% worldwide prevalence in adults. It has been associated with non-adherence to therapeutic regime with a negative impact on the prognosis of the disease and healthcare-associated costs. So, it is necessary to identify effective interventions to improve adherence among the afflicted population. The objective of this protocol is to describe the methods for a systematic review that will evaluate the effect of individual interventions so as to improve adherence to the prescribed pharmacological treatment, as well as to prescribed diet and physical activity in adults with primary hypertension.
A systematic search of studies will be conducted in PubMed/MEDLINE, BVS, CINAHL, Embase, Cochrane and Scopus databases. Randomised and non-randomised clinical studies conducted in human beings, published from 1 January 2009 to 13 December 2019, are to be included, in any language. Adherence to pharmacological treatment, diet and physical activity, measured by direct and indirect methods, will be the primary outcome. Two independent reviewers will select relevant studies and will extract the data following the Cochrane's Handbook for Systematic Reviews of Approach and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols. Methodological quality will be evaluated using the risk-of-bias (RoB) 2 and Risk of Bias in Non-randomised Studies - of Interventions (ROBINS-I) tools. Risk of bias will also be evaluated, and if the criteria are met, a meta-analysis will be finally performed.
Information to be analysed is of a grouped nature, and given that its sources are published studies, no ethics committee approval is required. Results will be published in scientific journals, and in conferences, seminars and symposiums. Copyrights will be addressed by giving due credit through bibliographic references.
CRD42020147655.
高血压是一种慢性病，全球成年人患病率为31%。它与不遵守治疗方案有关，对疾病预后和医疗相关成本产生负面影响。因此，有必要确定有效的干预措施，以提高患病人群的依从性。本方案的目的是描述一项系统评价的方法，该评价将评估个体干预措施的效果，以提高原发性高血压成年人对规定药物治疗、规定饮食和体育活动的依从性。
将在PubMed/MEDLINE、BVS、CINAHL、Embase、Cochrane和Scopus数据库中对研究进行系统检索。纳入2009年1月1日至2019年12月13日发表的、以任何语言撰写的、在人类中进行的随机和非随机临床研究。通过直接和间接方法测量的对药物治疗、饮食和体育活动的依从性将作为主要结果。两名独立的评审员将选择相关研究，并按照Cochrane系统评价方法手册和系统评价与Meta分析方案的首选报告项目提取数据。将使用偏倚风险（RoB）2和非随机干预研究中的偏倚风险（ROBINS-I）工具评估方法学质量。还将评估偏倚风险，如果符合标准，最终将进行Meta分析。
待分析的信息具有分组性质，鉴于其来源是已发表的研究，无需伦理委员会批准。结果将发表在科学期刊上，并在会议、研讨会和座谈会上公布。将通过参考文献给予适当的引用以解决版权问题。
PROSPERO注册号：CRD42020147655。
