Newcastle University Centre for Cancer, Newcastle University, Newcastle upon Tyne, UK.
Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
BMJ Open. 2020 Dec 21;10(12):e041073. doi: 10.1136/bmjopen-2020-041073.
Childhood cancer survivors (CCSs) treated with cardiotoxic cancer treatments are at increased risk of developing cardiometabolic complications. This risk is further exacerbated by poor health behaviours. In particular, CCSs are less active than non-cancer comparators. Existing interventions aiming to improve physical activity (PA) levels in CCSs are methodologically weak. The aim of this study is to rigorously and systematically develop an evidence-based and theoretically-informed intervention to promote, support, improve and sustain PA levels in CCSs, with the long-term goal of reducing CCSs' cardiovascular morbidity and mortality.
The BEing Active after ChildhOod caNcer (BEACON) study involves two workpackages at two National Health Service sites in England, UK.Participants will be CCSs and their parents, and healthcare professionals (HCPs) involved in their care.Workpackage one (WP1) will use qualitative methods to explore and understand the barriers and facilitators to PA in CCSs. Two sets of semistructured interviews will be conducted with (1) CCSs (aged 10-24 years) and (2) parents of CCSs. WP2 will use co-design methods to bring together stakeholders (CCSs; their parents; HCPs; researchers) to develop a prototype intervention. Where possible, all data will be audio recorded and transcribedData from WP1 will be analysed using a thematic approach. Analysis of WP2 data will involve content analysis, and analysis of formative output and procedures.
The study was approved by North East-Tyne & Wear South Research Ethics Committee (REC ref: 18/NE/0274). Research findings will be disseminated primarily via national and international conferences and publication in peer-reviewed journals. Patient and public involvement will inform further dissemination activities.
接受过心脏毒性癌症治疗的儿童癌症幸存者（CCS）发生心脏代谢并发症的风险增加。健康行为不佳进一步加剧了这种风险。特别是，CCS 的活动量比非癌症对照组少。旨在提高 CCS 身体活动（PA）水平的现有干预措施在方法上存在弱点。本研究的目的是严格系统地开发基于证据和理论的干预措施，以促进、支持、改善和维持 CCS 的 PA 水平，长期目标是降低 CCS 的心血管发病率和死亡率。
BEing Active after ChildhOod caNcer（BEACON）研究在英国英格兰的两个国家卫生服务机构的两个工作包中进行。参与者将是 CCS 及其父母，以及参与其护理的医疗保健专业人员（HCP）。工作包一（WP1）将使用定性方法来探索和了解 CCS 进行 PA 的障碍和促进因素。将对 CCS（年龄 10-24 岁）和 CCS 父母进行两组半结构化访谈。WP2 将使用共同设计方法将利益相关者（CCS；他们的父母；HCP；研究人员）聚集在一起，制定一个原型干预措施。在可能的情况下，所有数据都将进行录音和转录。WP1 的数据将使用主题方法进行分析。WP2 数据的分析将涉及内容分析以及形成性输出和程序的分析。
该研究已获得东北泰恩威尔南研究伦理委员会（REC 参考：18/NE/0274）的批准。研究结果将主要通过国家和国际会议以及同行评议期刊的发表来传播。患者和公众的参与将为进一步的传播活动提供信息。
