Xiangya School of Nursing, Central South University, Changsha, Hunan, China.
Teaching and Research Section of Clinical Nursing, Xiangya Hospital, Central South University, Changsha, Hunan, China
BMJ Open. 2023 Nov 14;13(11):e074162. doi: 10.1136/bmjopen-2023-074162.
Childhood cancer survivors (CCSs) who transition through adolescence and enter young adulthood may suffer psychological, cognitive, social, fertility, and sexual issues and concerns. There is an urgent need for comprehensive intervention strategies to improve the transition of CCSs. Web-based technologies are gaining momentum as a new mechanism to provide healthcare and education for adolescents. However, previous frameworks have been limited in their effectiveness in explaining web-based interventions.This realist synthesis aims to synthesise current evidence on transition of CCSs to develop a framework for web-based interventions. The framework can foster understanding of the integrity of web-based intervention implementation chain, examine which mechanistic factors will be triggered by web-based interventions, note and examine the flows, blockages and points of contention in the implementation, to refine web-based interventions.
A realist synthesis that adheres to the Realist and Meta-narrative Evidence Syntheses-Evolving Standard will be used. Studies will be identified through PubMed, Web of Science, EMBASE, PsycINFO, CINAHL, Ovid and Cochrane Library from the period of January 2005 to May 2023. We will also search the reference lists provided in relevant studies and reviews. Articles will be screened based on two principles: (1) Relevance: does the research address the initial programme theory? (2) Rigour: whether a particular inference drawn by the original researcher has sufficient weight to make a methodologically credible contribution to the test of the initial programme theory. No restrictions regarding the design or language of publication will be considered.
As a review, ethical approval is not required. The results from this study will be presented at international conferences and disseminated through peer-reviewed publications. Patients and the public will be involved in the dissemination plans.
童年癌症幸存者（CCS）在经历青春期并进入青年期时，可能会面临心理、认知、社交、生育和性问题和担忧。因此，迫切需要综合干预策略来改善 CCS 的过渡。基于网络的技术作为为青少年提供医疗保健和教育的新机制正在兴起。然而，以前的框架在解释基于网络的干预措施方面效果有限。本真实主义综合旨在综合当前关于 CCS 过渡的证据，为基于网络的干预措施制定框架。该框架可以促进对基于网络的干预实施链完整性的理解，检查基于网络的干预措施将触发哪些机制因素，注意和检查实施中的流程、障碍和争议点，以完善基于网络的干预措施。
将使用符合真实主义和元叙述证据综合-不断发展标准的真实主义综合。将通过 PubMed、Web of Science、EMBASE、PsycINFO、CINAHL、Ovid 和 Cochrane Library 从 2005 年 1 月至 2023 年 5 月期间确定研究。我们还将搜索相关研究和综述中提供的参考文献列表。根据两个原则筛选文章：（1）相关性：研究是否涉及初始方案理论？（2）严谨性：原始研究人员得出的特定推论是否具有足够的权重，为初始方案理论的检验提供方法上可信的贡献。不考虑设计或发布语言的限制。
由于这是一项综述，因此不需要伦理批准。本研究的结果将在国际会议上展示，并通过同行评审出版物传播。患者和公众将参与传播计划。
