Antoniac Iulian, Adam Răzvan, Biță Ana, Miculescu Marian, Trante Octavian, Petrescu Ionuț Mircea, Pogărășteanu Mark
Faculty of Materials Science and Engineering, University Politehnica of Bucharest, 313 Splaiul Independentei, 060042 Bucharest, Romania.
Orthopedic Department, Clinical University Emergency Hospital Elias, 17 Mărăști Blvd., 011461 Bucharest, Romania.
Materials (Basel). 2020 Dec 26;14(1):84. doi: 10.3390/ma14010084.
Use of magnesium implants is a new trend in orthopedic research because it has several important properties that recommend it as an excellent resorbable biomaterial for implants. In this study, the corrosion rate and behavior of magnesium alloys during the biodegradation process were determined by in vitro assays, evolution of hydrogen release, and weight loss, and further by in vivo assays (implantation in rabbits' bone and muscle tissue). In these tests, we also used imaging assessments and histological examination of different tissue types near explants. In our study, we analyzed the Mg-1Ca alloy and all the hypotheses regarding the toxic effects found in in vitro studies from the literature and those from this in vitro study were rejected by the data obtained by the in vivo study. Thus, the Mg-1Ca alloy represents a promising solution for orthopedic surgery at the present time, being able to find applicability in the small bones: hand or foot.
镁植入物的使用是骨科研究中的一个新趋势，因为它具有几个重要特性，使其成为一种出色的可吸收植入生物材料。在本研究中，通过体外试验、氢气释放量变化和重量损失来测定镁合金在生物降解过程中的腐蚀速率和行为，还通过体内试验（植入兔骨和肌肉组织）进行测定。在这些试验中，我们还对外植体附近不同组织类型进行了成像评估和组织学检查。在我们的研究中，我们分析了Mg-1Ca合金以及文献中体外研究发现的所有关于毒性作用的假设，而来自本体外研究的这些假设被体内研究获得的数据所否定。因此，Mg-1Ca合金目前代表了骨科手术的一个有前景的解决方案，能够在手部或足部等小骨骼中找到应用。
