Tolksdorf W, Rohowsky R, Klose R, Lutz H
Prakt Anaesth. 1979 Feb;14(1):52-8.
In 32 patients between 53 and 86 years of age, undergoing transurethral prostatectomy, the influence of intraoperative sedation with Diazepam (5-10 mg) and Flunitrazepam (0,4-0,8 mg) on postoperative forced vital capacity, forced exspiratory volume (1 sec.) and peakflow, were measured, compared to placebo. We could not find a depression of these ventilatory parameters, in the three groups except peak-flow after sedation with Flunitrazepam in the evening after operation (p less than or equal to 0,05). We conclude that sedation during regional anesthesia does not impair the most important advantage of local anesthesia, the minor effect on ventilation, compared with general anesthesia.
在32例年龄在53至86岁之间接受经尿道前列腺切除术的患者中，与安慰剂相比，测量了术中使用地西泮（5 - 10毫克）和氟硝西泮（0.4 - 0.8毫克）镇静对术后用力肺活量、用力呼气量（1秒）和峰值流速的影响。除术后当晚使用氟硝西泮镇静后的峰值流速外（p小于或等于0.05），我们在三组中均未发现这些通气参数降低。我们得出结论，与全身麻醉相比，区域麻醉期间的镇静不会损害局部麻醉最重要的优势，即对通气的影响较小。
