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水飞蓟素对人头皮毛囊真皮乳头细胞增殖及抗氧化活性的改善作用：与维生素C效果的比较

Improvement of Cell Proliferation and Antioxidant Activity of Silymarin in Hair Follicles Dermal Papillae Isolated from the Human Scalp: Comparison with Vitamin C Effects.

作者信息

Ashtiani Hamid Reza Ahmadi, Dadgar Asma, Akaberi Melika

机构信息

Department of Basic Sciences, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.

Cosmetic, Hygienic and Detergent Sciences and Technology Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.

出版信息

Int J Trichology. 2020 Jul-Aug;12(4):168-175. doi: 10.4103/ijt.ijt_124_19. Epub 2020 Sep 19.

DOI:10.4103/ijt.ijt_124_19
PMID:33376286
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7759063/
Abstract

INTRODUCTION

Nowadays, hair loss is becoming a major problem for a large number of people. The main factors affecting hair growth include racial, gender, genetics, and hormonal. Furthermore, environment, physiology, and nutrition are the tools that are affecting hair growth.

MATERIALS AND METHODS

This article analyses the effects of silymarin and Vitamin C on the proliferation of dermal papilla cells (DPCs), COX2, inducible nitric oxide synthase (iNOS), total anti-oxidant capacity (TAC), and reactive oxygen species (ROS). The DPCs of the hair follicle treated by 50 and 100 μM of silymarin and 100 μM of Vitamin C on days 2, 7, and 14.

RESULTS

A comparatively effect of silymarin and Vitamin C demonstrated that Vitamin C is more effective in the stimulation of dermal papillae in cell culture. Furthermore, the stimulation effects of silymarin are attributed to its antioxidant activity of the cells.

CONCLUSION

The overall result shows that cell proliferation and TAC significantly increased. However, iNOS, ROS, and COX2 levels were decreased.

摘要

引言

如今，脱发正成为众多人的一个主要问题。影响头发生长的主要因素包括种族、性别、遗传和激素。此外，环境、生理和营养也是影响头发生长的因素。

材料与方法

本文分析了水飞蓟素和维生素C对毛乳头细胞（DPCs）增殖、COX2、诱导型一氧化氮合酶（iNOS）、总抗氧化能力（TAC）和活性氧（ROS）的影响。在第2天、第7天和第14天，用50和100μM的水飞蓟素以及100μM的维生素C处理毛囊的DPCs。

结果

水飞蓟素和维生素C的比较效果表明，在细胞培养中维生素C在刺激毛乳头方面更有效。此外，水飞蓟素的刺激作用归因于其对细胞的抗氧化活性。

结论

总体结果表明细胞增殖和TAC显著增加。然而，iNOS、ROS和COX2水平降低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69f7/7759063/198dcc5ad891/IJT-12-168-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69f7/7759063/d6c75df38ad1/IJT-12-168-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69f7/7759063/49d5f95bdcfe/IJT-12-168-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69f7/7759063/1043244707f4/IJT-12-168-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69f7/7759063/4fe04181a7c1/IJT-12-168-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69f7/7759063/198dcc5ad891/IJT-12-168-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69f7/7759063/d6c75df38ad1/IJT-12-168-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69f7/7759063/49d5f95bdcfe/IJT-12-168-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69f7/7759063/1043244707f4/IJT-12-168-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69f7/7759063/4fe04181a7c1/IJT-12-168-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69f7/7759063/198dcc5ad891/IJT-12-168-g005.jpg

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