Itokawa Takashi, Suzuki Takashi, Iwashita Hiroko, Hori Yuichi
Department of Ophthalmology, Toho University Graduate School of Medicine, Tokyo, Japan.
Department of Ophthalmology, School of Medicine, Toho University, Tokyo, Japan.
Clin Ophthalmol. 2020 Dec 21;14:4459-4468. doi: 10.2147/OPTH.S288047. eCollection 2020.
Prelens tear film stability of soft contact lens (SCL) play an important role for contact lens discomfort. In this study, we investigated the association between two types of noninvasive methods and evaluated the tear film stability with SCL using the methods.
In experiment 1, images of ring mire were recorded with a keratograph after focusing the pigment located at the front or back of the SCL. Interferometry and videokeratoscopy were used for the assessment of tear film stability in the right eye of 10 women, with two different cosmetic daily disposable SCLs: polymacon and etafilcon A with polyvinylpyrrolidone. Time to first distortion by noninvasive keratograph break up time (NIKBUT-first) was compared to noninvasive interferometry break up time (NIBUT). In experiment 2, ten normal females wore two different daily disposable SCLs: samfilcon A and narafilcon A. NIKBUT-first and NIBUT were compared between the lenses after 8 hours of SCL wearing.
In experiment 1, NIBUT-first without SCL was significantly correlated to NIBUT without SCL (r=0.445, P=0.0488, Pearson's correlation coefficients). However, NIKBUT-first with SCL was not significantly correlated with NIBUT with SCL. In experiment 2, although NIKBUT-first was not significantly different between SCLs, samfilcon A had significantly longer NIBUT than narafilcon A (P=0.0315, paired -test).
NIKBUT-first with SCL could be related to tear film stability between the lens and the corneal surface, but not to prelens tear film stability. NIIBUT could be a suitable method to evaluate prelens tear stability.
软性接触镜（SCL）的镜片前泪膜稳定性在接触镜不适方面起着重要作用。在本研究中，我们调查了两种非侵入性方法之间的关联，并使用这些方法评估了SCL的泪膜稳定性。
在实验1中，使用角膜地形图仪在聚焦位于SCL前后的色素后记录环形视标图像。采用干涉测量法和视频角膜镜检查法对10名女性右眼的泪膜稳定性进行评估，她们佩戴两种不同的日抛型美容软性接触镜：聚甲基丙烯酸甲酯和含聚乙烯吡咯烷酮的依他氟康A。将无创角膜地形图仪测量的首次泪膜破裂时间（NIKBUT-first）与无创干涉测量法测量的泪膜破裂时间（NIBUT）进行比较。在实验2中，10名正常女性佩戴两种不同的日抛型软性接触镜：山富康A和那他氟康A。在佩戴SCL 8小时后，比较两种镜片之间的NIKBUT-first和NIBUT。
在实验1中，无SCL时的NIBUT-first与无SCL时的NIBUT显著相关（r = 0.445，P = 0.0488，Pearson相关系数）。然而，有SCL时的NIKBUT-first与有SCL时的NIBUT无显著相关性。在实验2中，虽然不同SCL之间的NIKBUT-first无显著差异，但山富康A的NIBUT明显长于那他氟康A（P = 0.0315，配对t检验）。
有SCL时的NIKBUT-first可能与镜片和角膜表面之间的泪膜稳定性有关，但与镜片前泪膜稳定性无关。NIIBUT可能是评估镜片前泪膜稳定性的合适方法。
