Nagayama Chihiro, Burns Stephen F, Stensel David J, Thackray Alice E, Takahashi Masaki, Miyashita Masashi
Graduate School of Sport Sciences, Waseda University, Tokorozawa, Japan.
Physical Education and Sports Science Academic Group, National Institute of Education, Nanyang Technological University, Singapore.
BMJ Open Sport Exerc Med. 2020 Dec 16;6(1):e000928. doi: 10.1136/bmjsem-2020-000928. eCollection 2020.
Elevated non-fasting triglyceride (TG) concentrations are a risk factor for cardiovascular diseases but can be reduced after acute exercise. Ethnic-based differences in the magnitude of postprandial lipaemia and the extent that acute exercise reduces postprandial TG are poorly characterised across some ethnicities including those of East Asian origin. This paper describes the protocol of a multisite randomised crossover study comparing the effect of acute walking on postprandial TG in two groups of East Asian men with European men.
Twenty Japanese, 20 Singaporean Chinese and 20 white British healthy men (21-39 years) recruited from Japan, Singapore and the UK, respectively, will complete two, 2-day trials. Fasted and postprandial venous blood samples and arterial blood pressure measurements will be taken over 6 hours the day after either: (1) 60-min treadmill walking; or (2) a rest day of normal living. The primary outcome is the difference in postprandial TG among ethnic groups after rest and walking. Secondary outcomes include cholesterol, glucose, insulin, ketone bodies, preheparin lipoprotein lipase, C-reactive protein and systolic/diastolic blood pressure.
The study was approved by the Ethics Review Committee on Research with Human Subjects of Waseda University and the Nanyang Technological University Institutional Review Board. Relevant approval will be obtained from the UK site. Research findings will be disseminated through peer-reviewed journal publication and health conferences.
UMIN000038625.
非空腹甘油三酯（TG）浓度升高是心血管疾病的一个危险因素，但急性运动后其浓度可降低。在包括东亚裔在内的一些种族中，餐后血脂异常的程度以及急性运动降低餐后TG的程度存在基于种族的差异，但目前对此了解甚少。本文描述了一项多中心随机交叉研究的方案，该研究比较了两组东亚男性与欧洲男性中急性步行对餐后TG的影响。
分别从日本、新加坡和英国招募20名日本、20名新加坡华裔和20名英国白人健康男性（21 - 39岁），他们将完成两项为期2天的试验。在以下两种情况后的第二天，在6小时内采集空腹和餐后静脉血样本并测量动脉血压：（1）60分钟跑步机步行；或（2）正常生活的休息日。主要结局是休息和步行后不同种族间餐后TG的差异。次要结局包括胆固醇、葡萄糖、胰岛素、酮体、肝素前脂蛋白脂肪酶、C反应蛋白以及收缩压/舒张压。
该研究获得了早稻田大学人体研究伦理审查委员会和南洋理工大学机构审查委员会的批准。将从英国研究地点获得相关批准。研究结果将通过同行评审期刊发表和健康会议进行传播。
UMIN000038625。
