Aldred H E, Perry I C, Hardman A E
Department of Physical Education, Sports Science and Recreation Management, Loughborough University, Leicestershire, England.
Metabolism. 1994 Jul;43(7):836-41. doi: 10.1016/0026-0495(94)90263-1.
The purpose of this study was to examine the effect of one bout of low-intensity exercise on the lipemic response to a high-fat meal. Twelve (six women, six men) normolipidemic adults aged 25.8 +/- 1.2 years (mean +/- SEM) took part in two trials. In the exercise trial, subjects walked for 2 hours on a treadmill at 30.9% +/- 1.6% of maximal oxygen uptake (VO2 max) 15 hours before ingestion of the test meal. In the control trial, subjects rested the day before the test meal. After a 12-hour fast, blood samples were obtained by venous cannulation before ingestion and hourly after ingestion for 6 hours. Serum was analyzed for triacylglycerol (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and HDL2-C, apolipoproteins (apos) A-I and B, free fatty acids (FFA), free glycerol, glucose, and insulin. TG values were corrected for free glycerol. Fasting serum TG and peak TG concentrations were lower (Wilcoxon, P < .05) for the exercise trial than for the control trial (0.74 +/- 0.03 v 0.92 +/- 0.08 and 1.98 +/- 0.18 v 2.59 +/- 0.32 mmol.L-1, respectively). The total lipemic response (area under the TG/time curve, normalized to the 0-hour level) was 31% +/- 7% lower in the exercise trial (4.28 +/- 0.66 v 6.46 +/- 1.08 mmol.L-1.h, P < .01). No differences were found between trials in the other parameters. These results show that a single bout of low-intensity exercise reduces the extent of postprandial lipemia in normolipidemic young adults. One possible mechanism is enhanced lipoprotein lipase (LPL) activity in the exercised skeletal muscle.
本研究的目的是检验一次低强度运动对高脂餐血脂反应的影响。12名（6名女性，6名男性）年龄为25.8±1.2岁（均值±标准误）的血脂正常成年人参与了两项试验。在运动试验中，受试者在摄入试验餐15小时前在跑步机上以最大摄氧量（VO2 max）的30.9%±1.6%的强度步行2小时。在对照试验中，受试者在试验餐前一天休息。禁食12小时后，在摄入前通过静脉插管采集血样，并在摄入后每小时采集一次，共采集6小时。分析血清中的三酰甘油（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）和HDL2-C、载脂蛋白（apo）A-I和B、游离脂肪酸（FFA）、游离甘油、葡萄糖和胰岛素。TG值校正了游离甘油。运动试验的空腹血清TG和TG峰值浓度低于对照试验（Wilcoxon检验，P<0.05）（分别为0.74±0.03和0.92±0.08以及1.98±0.18和2.59±0.32 mmol.L-1）。运动试验的总血脂反应（TG/时间曲线下面积，以0小时水平标准化）比对照试验低31%±7%（4.28±0.66和6.46±1.08 mmol.L-1.h，P<0.01）。其他参数在两项试验之间未发现差异。这些结果表明，一次低强度运动可降低血脂正常的年轻成年人餐后血脂升高的程度。一种可能的机制是运动的骨骼肌中脂蛋白脂肪酶（LPL）活性增强。
