Department of Gastroenterology, Central Clinical School, Monash University and Alfred Hospital, Melbourne, Victoria, 3004, Australia.
Department of Immunology and Pathology, Central Clinical School, Monash University and Alfred Hospital, Melbourne, Victoria, 3004, Australia.
Mol Nutr Food Res. 2021 Feb;65(4):e2000953. doi: 10.1002/mnfr.202000953. Epub 2021 Jan 22.
To promote local and systemic benefits of short-chain fatty acids (SCFA), methods of increasing their delivery to the gastrointestinal tract are needed. SCFA in foods and beverages represents a poorly characterized source. Main aims of this study are: 1) quantify SCFA in commonly consumed foods and beverages, and 2) explore the pharmacokinetics of consuming oral SCFA from dietary sources.
Gas-chromatography coupled to flame ionization detection is used measure SCFA in 38 commonly consumed foods and beverages. Acetate is the most abundant SCFA detected, with kombucha and vinegar found to provide >1000 mg of acetate per serve. An acute pharmacokinetic study is conducted in 10 participants. Acetate is stable across the 2-h sampling period after consumption of a control drink, with consumption of a vinegar drink containing 25 mmol acetate significantly increasing plasma acetate concentration after 60 min and increasing acetate delivery to the blood upon assessment of the area under the pharmacokinetic curve.
Fermented foods and beverages are a natural source of dietary SCFA that acutely deliver SCFA to the blood. If systemic delivery is needed for immunological and metabolic effects to occur, these may be achieved if delivered over a longer period of time.
为了促进短链脂肪酸（SCFA）的局部和全身益处，需要寻找增加其向胃肠道输送的方法。食物和饮料中的 SCFA 代表了一种特征描述较差的来源。本研究的主要目的是：1）定量分析常见食用食物和饮料中的 SCFA，2）探索从饮食来源摄入口服 SCFA 的药代动力学。
使用气相色谱法结合火焰离子化检测来测量 38 种常见食用食物和饮料中的 SCFA。乙酸是检测到的最丰富的 SCFA，发现康普茶和醋每份提供超过 1000mg 的乙酸。对 10 名参与者进行了一项急性药代动力学研究。在饮用对照饮料后 2 小时的采样期间，乙酸保持稳定，饮用含有 25mmol 乙酸的醋饮料会在 60 分钟后显著增加血浆乙酸浓度，并在评估药代动力学曲线下面积时增加乙酸向血液的输送。
发酵食品和饮料是膳食 SCFA 的天然来源，可急性向血液输送 SCFA。如果需要全身性输送以产生免疫和代谢作用，则如果在较长时间内输送，可能会实现这一目标。
