Institute of Integrated Clinical Practice, Faculty of Medicine, University of Coimbra, 3000-075 Coimbra, Portugal.
Area of Environment Genetics and Oncobiology (CIMAGO), Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.
Int J Mol Sci. 2020 Dec 31;22(1):353. doi: 10.3390/ijms22010353.
Cavity disinfection becomes an important step before a dental restorative procedure. The disinfection can be obtained cleaning the dental cavity with antimicrobial agents before the use of adhesive systems. The aim of this study was to conduct a systematic review on the effect of different cavity disinfectants on restorations' adhesion and clinical success. A search was carried out through the Cochrane Library, PubMed, and Web of Science. In vitro and in situ studies reporting results on dentin bond strength tests, and clinical studies published until August 2020, in English, Spanish and Portuguese were included. The methodological quality assessment of the clinical studies was carried out using the Revised Cochrane risk-of-bias tool. Chlorhexidine could preserve adhesion to dentin. EDTA and ethanol had positive results that should be further confirmed. Given the significant lack of scientific evidence, the use of lasers, fluoridated agents, sodium hypochlorite, or other products as cavity disinfectants should be avoided. Chlorhexidine is a safe option for cavity disinfection with adequate preservation of adhesion to dentin. Moreover, future researches should be focused on the efficacy of these disinfectants against cariogenic bacteria and their best application methods.
窝洞消毒是牙体修复前的重要步骤。在使用粘接系统之前，可以用抗菌剂清洁牙洞来进行消毒。本研究旨在对不同窝洞消毒剂对修复体粘接和临床效果的影响进行系统评价。通过 Cochrane 图书馆、PubMed 和 Web of Science 进行了检索。纳入了报告有关牙本质粘结强度测试结果的体外和原位研究，以及截至 2020 年 8 月发表的英文、西班牙文和葡萄牙文的临床研究。使用修订后的 Cochrane 偏倚风险工具对临床研究的方法学质量进行了评估。洗必泰可以保持对牙本质的粘结。EDTA 和乙醇的结果呈阳性，但需要进一步证实。鉴于缺乏科学证据，应避免使用激光、氟化物制剂、次氯酸钠或其他产品作为窝洞消毒剂。洗必泰是一种安全的窝洞消毒选择，对牙本质的粘结有足够的保留作用。此外，未来的研究应集中在这些消毒剂对抗致龋菌的效果及其最佳应用方法上。
