Miranda Evelyn Alejandra, Han Sun-Woo, Cho Yoon-Kyong, Choi Kyoung-Seong, Chae Joon-Seok
Laboratory of Veterinary Internal Medicine, BK21 PLUS Program for Creative Veterinary Science Research, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea.
College of Ecology and Environmental Science, Kyungpook National University, Sangju 37224, Korea.
Pathogens. 2021 Jan 1;10(1):28. doi: 10.3390/pathogens10010028.
Anaplasmosis, a tick-borne disease with multiple reservoirs, has been evolving in its pathogenesis, increasing domestic ruminants susceptibility to simultaneous infections with multiple pathogens. However, there is limited information regarding anaplasmosis in domestic ruminants in the Republic of Korea (ROK). We aimed to evaluate the role of Korean cattle and goats in infection maintenance. Polymerase chain reaction was performed to investigate the prevalence and genetic diversity of spp. from 686 whole blood samples collected from different ROK provinces. infection was mostly caused by (21.1%) in cattle, and (7.3%) in goats. Co-infection cases were found in cattle: and (16.7%), and in goats: and (1.0%). Notably, a triple co-infection with , , and was found in one cow. Phylogenetic analysis revealed novel variants of the and genes. This research contributes to the ratification of cattle as a potential reservoir of and demonstrates co-infection types in Korean domestic ruminants. As anaplasmosis is a zoonotic disease, our study could be crucial in making important decisions for public health.
无形体病是一种由蜱传播且有多个宿主的疾病，其发病机制一直在演变，导致国内反刍动物更容易同时感染多种病原体。然而，关于大韩民国（韩国）国内反刍动物无形体病的信息有限。我们旨在评估韩国牛和山羊在感染维持中的作用。采用聚合酶链反应来调查从韩国不同省份采集的686份全血样本中无形体属物种的流行情况和遗传多样性。牛的感染主要由嗜吞噬细胞无形体（21.1%）引起，山羊的感染主要由边缘无形体（7.3%）引起。在牛中发现了共感染病例：嗜吞噬细胞无形体和牛无形体（16.7%），在山羊中发现了：边缘无形体和绵羊无形体（1.0%）。值得注意的是，在一头奶牛中发现了嗜吞噬细胞无形体、牛无形体和绵羊无形体的三重共感染。系统发育分析揭示了嗜吞噬细胞无形体和牛无形体基因的新变体。这项研究有助于认可牛作为嗜吞噬细胞无形体的潜在宿主，并展示了韩国国内反刍动物的共感染类型。由于无形体病是一种人畜共患病，我们的研究对于做出公共卫生方面的重要决策可能至关重要。
