Wongchitrat Prapimpun, Shukla Mayuri, Sharma Ramaswamy, Govitrapong Piyarat, Reiter Russel J
Center for Research and Innovation, Faculty of Medical Technology, Mahidol University, Nakhon Pathom 73170, Thailand.
Chulabhorn Graduate Institute, Chulabhorn Royal Academy, Bangkok 10210, Thailand.
Antioxidants (Basel). 2021 Jan 2;10(1):47. doi: 10.3390/antiox10010047.
Viral infections may cause neurological disorders by directly inducing oxidative stress and interrupting immune system function, both of which contribute to neuronal death. Several reports have described the neurological manifestations in Covid-19 patients where, in severe cases of the infection, brain inflammation and encephalitis are common. Recently, extensive research-based studies have revealed and acknowledged the clinical and preventive roles of melatonin in some viral diseases. Melatonin has been shown to have antiviral properties against several viral infections which are accompanied by neurological symptoms. The beneficial properties of melatonin relate to its properties as a potent antioxidant, anti-inflammatory, and immunoregulatory molecule and its neuroprotective effects. In this review, what is known about the therapeutic role of melatonin in virus-induced neuropathogenesis is summarized and discussed.
病毒感染可能通过直接诱导氧化应激和干扰免疫系统功能来引发神经紊乱，而这两者都会导致神经元死亡。有几份报告描述了新冠病毒肺炎患者的神经学表现，在严重感染病例中，脑部炎症和脑炎很常见。最近，大量基于研究的报告揭示并认可了褪黑素在一些病毒性疾病中的临床和预防作用。褪黑素已被证明对几种伴有神经症状的病毒感染具有抗病毒特性。褪黑素的有益特性与其作为一种强效抗氧化剂、抗炎和免疫调节分子的特性及其神经保护作用有关。在这篇综述中，总结并讨论了关于褪黑素在病毒诱导的神经发病机制中的治疗作用的已知信息。
