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1
Conformation of the synthetic DNA poly(amino2dA-dT) duplex in high-salt and aqueous alcohol solutions.合成DNA聚（氨基2dA-dT）双链体在高盐和醇水溶液中的构象。
Nucleic Acids Res. 1988 Jan 11;16(1):279-89. doi: 10.1093/nar/16.1.279.
2
Poly(amino2dA-dT) isomerizes into the unusual X-DNA double helix at physiological conditions inducing Z-DNA in poly (dG-methyl5dC).聚（氨基2dA-dT）在生理条件下异构化为不寻常的X-DNA双螺旋，从而在聚（dG-甲基5dC）中诱导Z-DNA形成。
J Biomol Struct Dyn. 1988 Dec;6(3):503-10. doi: 10.1080/07391102.1988.10506503.
3
Thymine methyl groups stabilize the putative A-form of the synthetic DNA poly(amino2dA-dT).胸腺嘧啶甲基基团稳定了合成DNA聚（氨基2dA-dT）的假定A形式。
Biochemistry. 1994 Apr 5;33(13):3801-6. doi: 10.1021/bi00179a003.
4
An A-form of poly(amino2dA-dT).poly(amino2dA-dT) induced by polyamines.一种由多胺诱导产生的聚（氨基-2dA-dT）的A形式。聚（氨基-2dA-dT）。
Biochemistry. 1993 Feb 2;32(4):1067-71. doi: 10.1021/bi00055a011.
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Recognition and use of the unusual X-DNA as a primer-template by Klenow DNA polymerase enzyme.克列诺夫DNA聚合酶对异常X-DNA作为引物模板的识别与利用。
Biochem Biophys Res Commun. 1989 Jun 30;161(3):1204-12. doi: 10.1016/0006-291x(89)91370-3.
6
Conformational variability of poly(dA-dT).poly(dA-dT) and some other deoxyribonucleic acids includes a novel type of double helix.聚（dA-dT）·聚（dA-dT）及其他一些脱氧核糖核酸的构象变异性包括一种新型双螺旋结构。
J Biomol Struct Dyn. 1985 Aug;3(1):67-83. doi: 10.1080/07391102.1985.10508399.
7
Thermal melting of poly(dA-dT).poly(dA-dT) in methanol-water solutions.聚（dA-dT）·聚（dA-dT）在甲醇-水溶液中的热变性
Biochem Biophys Res Commun. 1984 Sep 17;123(2):831-5. doi: 10.1016/0006-291x(84)90305-x.
8
Conformational isomerizations of the poly(dA-dT) and poly(amino2dA-dT) duplexes involving the unusual X-DNA double helix: a fourth derivative spectrophotometric study.涉及异常X-DNA双螺旋的聚（dA-dT）和聚（氨基2dA-dT）双链体的构象异构化：四阶导数分光光度法研究
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9
Replication, transcription and nuclease digestion of the unusual X-DNA double helix of poly(amino2dA-dT).聚（氨基-2dA-dT）异常X-DNA双螺旋的复制、转录和核酸酶消化
J Biomol Struct Dyn. 1990 Apr;7(5):1073-82. doi: 10.1080/07391102.1990.10508547.
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Conformational transitions of alternating purine-pyrimidine DNAs in perchlorate ethanol solutions.高氯酸盐乙醇溶液中交替嘌呤-嘧啶DNA的构象转变
Biophys J. 1995 Nov;69(5):2033-43. doi: 10.1016/S0006-3495(95)80073-1.

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A Chemical Approach to Introduce 2,6-Diaminopurine and 2-Aminoadenine Conjugates into Oligonucleotides without Need for Protecting Groups.一种无需保护基团即可将 2,6-二氨基嘌呤和 2-氨基腺嘌呤缀合到寡核苷酸中的化学方法。
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Nanomechanics of negatively supercoiled diaminopurine-substituted DNA.带负超螺旋的二氨基嘌呤取代 DNA 的纳米力学。
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Circular dichroism and conformational polymorphism of DNA.DNA的圆二色性与构象多态性
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Molecular recognition in the minor groove of the DNA helix. Studies on the synthesis of oligonucleotides and polynucleotides containing 3-deaza-2'-deoxyadenosine. Interaction of the oligonucleotides with the restriction endonuclease EcoRV.DNA螺旋小沟中的分子识别。含3-脱氮-2'-脱氧腺苷的寡核苷酸和多核苷酸的合成研究。寡核苷酸与限制性内切酶EcoRV的相互作用。
Nucleic Acids Res. 1990 Aug 25;18(16):4771-8.
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Transitions of poly(dI-dC), poly(dI-methyl5dC) and poly(dI-bromo5dC) among and within the B-, Z-, A- and X-DNA families of conformations.聚（dI-dC）、聚（dI-甲基5dC）和聚（dI-溴5dC）在B-、Z-、A-和X-DNA构象家族之间以及内部的转变。
Nucleic Acids Res. 1991 May 11;19(9):2343-7. doi: 10.1093/nar/19.9.2343.
6
Comparative NMR analysis of the decadeoxynucleotide d-(GCATTAATGC)2 and an analogue containing 2-aminoadenine.十脱氧核苷酸d-(GCATTAATGC)2与含2-氨基腺嘌呤类似物的核磁共振对比分析。
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本文引用的文献

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A STUDY OF CONFORMATION OF NUCLEIC ACIDS IN SOLUTION BY MEANS OF CIRCULAR DICHROISM.利用圆二色性研究溶液中核酸的构象
J Mol Biol. 1964 Oct;10:73-88. doi: 10.1016/s0022-2836(64)80029-2.
2
Polymorphism of DNA double helices.DNA双螺旋的多态性
J Mol Biol. 1980 Oct 15;143(1):49-72. doi: 10.1016/0022-2836(80)90124-2.
3
Structure of a B-DNA dodecamer. III. Geometry of hydration.B型DNA十二聚体的结构。III. 水合作用的几何学
J Mol Biol. 1981 Sep 25;151(3):535-56. doi: 10.1016/0022-2836(81)90009-7.
4
The transitions between left- and right-handed forms of poly(dG-dC).聚（dG-dC）左右手性形式之间的转变
Nucleic Acids Res. 1981 Sep 25;9(18):4783-98. doi: 10.1093/nar/9.18.4783.
5
Conformational transitions of poly(dA-dT)poly(dA-dT) in ethanolic solutions.聚（dA-dT）聚（dA-dT）在乙醇溶液中的构象转变。
Nucleic Acids Res. 1982 Nov 11;10(21):6969-79. doi: 10.1093/nar/10.21.6969.
6
The influence of the purine 2-amino group on DNA conformation and stability. Synthesis and conformational analysis of d[T(2-aminoA)]3.嘌呤2-氨基对DNA构象和稳定性的影响。d[T(2-氨基A)]3的合成与构象分析。
Nucleic Acids Res. 1982 Jul 24;10(14):4351-61. doi: 10.1093/nar/10.14.4351.
7
Conformational transitions of poly(dA-dC).poly(dG-dT) induced by high salt or in ethanolic solution.高盐或乙醇溶液诱导的聚（dA-dC）·聚（dG-dT）的构象转变
Nucleic Acids Res. 1982 Feb 11;10(3):1081-91. doi: 10.1093/nar/10.3.1081.
8
Z-DNA: vacuum ultraviolet circular dichroism.Z型DNA：真空紫外圆二色性
Proc Natl Acad Sci U S A. 1981 Aug;78(8):4801-4. doi: 10.1073/pnas.78.8.4801.
9
Salt-induced conformational transition of poly[d(A-T)] X poly[d(A-T)].聚[d(A-T)]×聚[d(A-T)]的盐诱导构象转变
J Mol Biol. 1983 May 5;166(1):85-92. doi: 10.1016/s0022-2836(83)80052-7.
10
Poly(d2NH2A-dT): effect of 2-amino substituent on the B to Z transition.
Biochem Biophys Res Commun. 1984 Feb 14;118(3):848-53. doi: 10.1016/0006-291x(84)91472-4.

合成DNA聚（氨基2dA-dT）双链体在高盐和醇水溶液中的构象。

Conformation of the synthetic DNA poly(amino2dA-dT) duplex in high-salt and aqueous alcohol solutions.

作者信息

Vorlícková M, Sági J, Szabolcs A, Szemzö A, Otvös L, Kypr J

机构信息

Institute of Biophysics, Czechoslovak Academy of Sciences, Brno.

出版信息

Nucleic Acids Res. 1988 Jan 11;16(1):279-89. doi: 10.1093/nar/16.1.279.

DOI:10.1093/nar/16.1.279
PMID:3340526
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC334626/
Abstract

It has previously been demonstrated by other workers that the duplex of a synthetic DNA poly(amino2dA-dT) undergoes a salt-induced conformational isomerization. We show in the present work using circular dichroism that the same isomerization is induced in poly(amino2dA-dT) by various alcohols. The isomerization was originally identified as the B-to-Z and then B-to-A conformational transition of DNA but we demonstrate that the high-salt or alcohol conformation of poly (amino2dA-dT) is the non Z-DNA zig-zag double helix we have previously observed with poly(dA-dT) and called X-DNA. X-DNA is a cesium cation specific conformation of poly(dA-dT) while no similar cation specificity is observed with poly(amino2dA-dT). Thus it appears that the extra amino group attached to A and cesium cations make the same thing; they probably dehydrate the double helix minor groove and relieve its conformational variability. Poly(amino2dA-dT) is exceptionally stable in X-DNA and conditions inducing it are mild, which opens the door to assess its molecular structure.

摘要

此前其他研究人员已证明，合成DNA聚（氨基2dA - dT）的双链体会发生盐诱导的构象异构化。我们在当前工作中利用圆二色性表明，各种醇类也能在聚（氨基2dA - dT）中诱导相同的异构化。这种异构化最初被确定为DNA的B型到Z型，然后是B型到A型的构象转变，但我们证明聚（氨基2dA - dT）的高盐或醇类构象是我们之前在聚（dA - dT）中观察到并称为X - DNA的非Z - DNA锯齿状双螺旋。X - DNA是聚（dA - dT）的一种铯阳离子特异性构象，而在聚（氨基2dA - dT）中未观察到类似的阳离子特异性。因此，似乎连接在A上的额外氨基和铯阳离子起到了相同的作用；它们可能使双螺旋小沟脱水并减轻其构象变异性。聚（氨基2dA - dT）在X - DNA中异常稳定，且诱导其形成的条件较为温和，这为评估其分子结构打开了大门。