Lee Taesic, Lee Hyunju
Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Artificial Intelligence Graduate School, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Biomedicines. 2021 Jan 4;9(1):34. doi: 10.3390/biomedicines9010034.
Alzheimer's disease (AD) and diabetes mellitus (DM) are known to have a shared molecular mechanism. We aimed to identify shared blood transcriptomic signatures between AD and DM. Blood expression datasets for each disease were combined and a co-expression network was used to construct modules consisting of genes with similar expression patterns. For each module, a gene regulatory network based on gene expression and protein-protein interactions was established to identify hub genes. We selected one module, where , , , , and were identified as dysregulated transcription factors that were common between AD and DM. These five genes were also differentially co-expressed in disease-related tissues, such as the brain in AD and the pancreas in DM. Our study identified gene modules that were dysregulated in both AD and DM blood samples, which may contribute to reveal common pathophysiology between two diseases.
已知阿尔茨海默病（AD）和糖尿病（DM）具有共同的分子机制。我们旨在识别AD和DM之间共享的血液转录组特征。将每种疾病的血液表达数据集合并，并使用共表达网络构建由具有相似表达模式的基因组成的模块。对于每个模块，基于基因表达和蛋白质-蛋白质相互作用建立基因调控网络以识别枢纽基因。我们选择了一个模块，其中，，，，和被鉴定为AD和DM之间共有的失调转录因子。这五个基因在疾病相关组织中也存在差异共表达，如AD中的大脑和DM中的胰腺。我们的研究识别出在AD和DM血液样本中均失调的基因模块，这可能有助于揭示两种疾病之间的共同病理生理学。
