School of Medicine and Health Management, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Qiaokou district, Wuhan, 430030, Hubei, China.
Department of Endocrinology, Affiliated Hospital of Jining Medical University, Jining Medical University, 89 Guhuai Road, Rencheng District, Jining, 272029, Shandong, China.
Lipids Health Dis. 2021 Jan 6;20(1):1. doi: 10.1186/s12944-020-01429-x.
Elevated triglyceride (TG) levels are a biomarker for cardiovascular disease (CVD) risk. The correlation between serum uric acid (SUA) and TG concentrations in adults or obese children is well established. However, studies on SUA and TG in children with short stature are limited.
To determine the relationship between SUA and TG levels in short children and adolescents.
This was a cross-sectional evaluation of a cohort of 1095 patients with short stature (720 males and 375 females). The related clinical characteristics, including anthropometric and biochemical parameters, were determined.
Smooth curve fitting, adjusted for potential confounders was performed, which indicated the existence of a non-linear relationship between these measures. Piecewise multivariate linear analysis revealed a significant positive relationship between SUA and TG at SUA concentrations over 7 mg/dL (β = 0.13, 95% CI: 0.05-0.22, P = 0.002) but no significant correlation at lower SUA levels (β = 0.01, 95% CI: 0.01-0.04, P = 0.799). Furthermore, a stratified analysis was performed to appraise changes in this relationship for different sexes and standard deviation levels of body mass index (BMI). The non-linear relationship remained consistent in males and females with BMI standard deviation scores (BMI SDS) ≥ 0, with inflection points of 6.71 mg/dL and 3.93 mg/dL, respectively. Within these two groups, SUA and TG levels showed a positive association when SUA levels were higher than the inflection point (β = 0.21, 95% CI: 0.11-0.31, P < 0.001 for males and β = 0.1, 95% CI: 0.03-0.17, P = 0.005 for females). However, a specific relationship was not observed at lower SUA levels. No significant relationships were found between SUA and TG levels in males and females with BMI SDS < 0.
The present study identified the non-linear association of SUA and TG levels with short children and adolescents. This relationship was based on BMI status. This finding suggests that health status should be considered for short stature children with high SUA levels, especially in children with a high BMI standard deviation score.
甘油三酯（TG）水平升高是心血管疾病（CVD）风险的生物标志物。血清尿酸（SUA）与成年人或肥胖儿童的 TG 浓度之间的相关性已得到充分证实。然而，关于身材矮小儿童的 SUA 和 TG 的研究有限。
确定身材矮小儿童和青少年中 SUA 和 TG 水平之间的关系。
这是对 1095 名身材矮小患者（720 名男性和 375 名女性）队列的横断面评估。确定了相关的临床特征，包括人体测量和生化参数。
对潜在混杂因素进行了平滑曲线拟合，结果表明这些指标之间存在非线性关系。分段多元线性分析显示，在 SUA 浓度超过 7mg/dL 时，SUA 和 TG 之间存在显著的正相关关系（β=0.13，95%CI：0.05-0.22，P=0.002），而在较低的 SUA 水平时无显著相关性（β=0.01，95%CI：0.01-0.04，P=0.799）。此外，还进行了分层分析以评估不同性别和体重指数（BMI）标准偏差水平下这种关系的变化。在 BMI 标准偏差得分（BMI SDS）≥0 的男性和女性中，这种非线性关系仍然一致，拐点分别为 6.71mg/dL 和 3.93mg/dL。在这两组中，当 SUA 水平高于拐点时，SUA 和 TG 水平呈正相关（β=0.21，95%CI：0.11-0.31，P<0.001 男性和β=0.1，95%CI：0.03-0.17，P=0.005 女性）。然而，在较低的 SUA 水平下没有观察到特定的关系。在 BMI SDS<0 的男性和女性中，SUA 和 TG 水平之间没有显著的相关性。
本研究确定了 SUA 和 TG 水平与身材矮小儿童和青少年之间的非线性关联。这种关系基于 BMI 状态。这一发现表明，对于 SUA 水平较高的身材矮小儿童，尤其是 BMI 标准偏差得分较高的儿童，应考虑其健康状况。
