Elkitkat Rania Serag, Fouad Yousef A, Shams Abdelrhman, Hamza Ismail
Ophthalmology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Watany Eye Hospital, Cairo, Egypt.
Clin Ophthalmol. 2020 Dec 31;14:4571-4577. doi: 10.2147/OPTH.S288738. eCollection 2020.
To determine the spherical aberration, pupil size, and other key refractive and topographic parameters in a large cohort of Egyptian cataract surgery candidates, and to investigate any existent relations between the spherical aberration and other possibly related parameters.
This is a cross-sectional, descriptive study that was conducted at Ain Shams University Hospitals, Cairo, Egypt. The study was performed on the right eyes of 1658 cataract surgery candidates. The mean corneal spherical aberration [Z4] and the pupil diameter, both photopic [P. Pupil] and mesopic [M. Pupil], were measured by the Oculus Keratograph 3, while the white-to-white corneal diameter [WTW], average keratometric readings [average K], axial length measurements [AL] and Anterior Chamber Depth [ACD] were all obtained from the IOL Master 500.
The mean age was 65 ± 11.3 years. The mean value of the Z4 was +0.26 ± 0.12 μm [95% Confidence Interval "CI" (0.2570-0.2681)]. The mean values of the measured parameters were: P. Pupil 2.43 ± 0.87 mm [95% CI (2.3867-2.4700)], M. Pupil 4.61 ± 0.91 mm [95% CI (4.5683-4.6557)], WTW 11.72 ± 0.44 mm [95% CI (11.6969-11.7394)], average K 43.89 ± 1.89 D [95% CI (43.7938-43.9701)], AL 24.23 ± 2.21 mm [95% CI (24.1118-24.3166)], and ACD 3.16 ± 0.43 mm [95% CI (3.1414-3.1827)]. Weak statistically significant correlations were found between the Z4 and each of age (r = 0.049, p = 0.044), average K (r = 0.191, p < 0.001), and ACD (r = 0.122, p < 0.001). Multivariate analysis showed weaker relations between Z4 and both average K (beta coefficient= 0.091) and ACD (beta coefficient= 0.130), with an r = 0.024.
This is the first normative data report of corneal spherical aberration [Z4], pupil size, and related refractive and topographic parameters in an old Egyptian population. The detected correlations have a weak clinical relevance and negate the existence of significant relations between the Z4 and the studied refractive and topographic parameters.
确定一大批埃及白内障手术候选者的球差、瞳孔大小以及其他关键屈光和地形学参数，并研究球差与其他可能相关参数之间是否存在关联。
这是一项在埃及开罗艾因夏姆斯大学医院进行的横断面描述性研究。该研究对1658名白内障手术候选者的右眼进行。使用Oculus Keratograph 3测量平均角膜球差[Z4]以及明视[P. Pupil]和 mesopic[M. Pupil]条件下的瞳孔直径，而角膜白到白直径[WTW]、平均角膜曲率读数[平均K]、眼轴长度测量值[AL]和前房深度[ACD]均从IOL Master 500获取。
平均年龄为65±11.3岁。Z4的平均值为+0.26±0.12μm[95%置信区间“CI”(0.2570 - 0.2681)]。所测参数的平均值分别为：P. Pupil 2.43±0.87mm[95%CI(2.3867 - 2.4700)]，M. Pupil 4.61±0.91mm[95%CI(4.5683 - 4.6557)]，WTW 11.72±0.44mm[95%CI(11.6969 - 11.7394)]，平均K 43.89±1.89D[95%CI(43.7938 - 43.9701)]，AL 24.23±2.21mm[95%CI(24.1118 - 24.3166)]，以及ACD 3.16±0.43mm[95%CI(3.1414 - 3.1827)]。发现Z4与年龄(r = 0.049，p = 0.044)、平均K(r = 0.191，p < 0.001)和ACD(r = 0.122，p < 0.001)之间存在微弱的统计学显著相关性。多变量分析显示Z4与平均K(β系数 = 0.091)和ACD(β系数 = 0.130)之间的关系较弱，r = 0.024。
这是关于老年埃及人群角膜球差[Z4]、瞳孔大小以及相关屈光和地形学参数的首份规范性数据报告。所检测到的相关性临床相关性较弱，否定了Z4与所研究的屈光和地形学参数之间存在显著关系。
