Department of General Surgery, Zhuhai People's Hospital, Zhuhai Hospital Affiliated with Jinan University, Jinan University, Zhuhai, China.
Zhuhai Interventional Medical Center, Zhuhai Precision Medical Center, Zhuhai People's Hospital, Zhuhai Hospital Affiliated with Jinan University, Jinan University, Zhuhai, China.
Front Immunol. 2020 Dec 21;11:601497. doi: 10.3389/fimmu.2020.601497. eCollection 2020.
Immunotherapies have been accelerating the development of anti-cancer clinical treatment, but its low objective responses and severe off-target immune-related adverse events (irAEs) limit the range of application. Strategies to remove these obstacles primarily focus on the combination of different therapies and the exploitation of new immunotherapeutic agents. Nanomedicine potentiates the effects of activating immune cells selectively and reversing tumor induced immune deficiency microenvironment through multiple mechanisms. In the last decade, a variety of nano-enabled tumor immunotherapies was under clinical investigation. As time goes by, the advantages of nanomedicine are increasingly prominent. With the continuous development of nanotechnology, nanomedicine will offer more distinctive perspectives in imaging diagnosis and treatment of tumors. In this Review, we wish to provide an overview of tumor immunotherapy and the mechanisms of nanomaterials that aim to enhance the efficacy of tumor immunotherapy under development or in clinic treatment.
免疫疗法一直在加速抗肿瘤临床治疗的发展，但它的客观反应率低和严重的脱靶免疫相关不良事件（irAEs）限制了其应用范围。消除这些障碍的策略主要集中在不同疗法的联合和新免疫治疗药物的开发上。纳米医学通过多种机制增强选择性激活免疫细胞和逆转肿瘤诱导的免疫缺陷微环境的效果。在过去的十年中，多种基于纳米技术的肿瘤免疫疗法正在进行临床研究。随着时间的推移，纳米医学的优势越来越明显。随着纳米技术的不断发展，纳米医学将在肿瘤的成像诊断和治疗方面提供更独特的视角。在这篇综述中，我们希望概述肿瘤免疫疗法和旨在提高正在开发或临床治疗中的肿瘤免疫疗法疗效的纳米材料的机制。
