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非洲的癌症:这是一个基因问题还是环境卫生问题?

Cancer in Africa: Is It a Genetic or Environmental Health Problem?

作者信息

Bahnassy Abeer A, Abdellateif Mona S, Zekri Abdel-Rahman N

机构信息

Tissue Culture and Cytogenetics Unit, Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt.

Medical Biochemistry and Molecular Biology, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt.

出版信息

Front Oncol. 2020 Dec 14;10:604214. doi: 10.3389/fonc.2020.604214. eCollection 2020.

Abstract

Patients of African ancestry have the poorest outcome and the shortest survival rates from cancer globally. This could be attributed to many variables including racial, biological, socioeconomic and sociocultural factors (either single, multiple or combined), which may be responsible for this major health problem. We sought to assess the most common types of cancer that endanger the health of the African people, and tried to investigate the real differences between African and other Non-African patients regarding incidence, prevalence and mortality rates of different cancers. Therefore, identifying the underlying aetiological causes responsible for the increased incidence and mortality rates of African patients will allow for changing the current plans, to make optimized modalities for proper screening, diagnosis and treatment for those African patients, in order to improve their survival and outcomes.

摘要

在全球范围内,非洲裔患者的癌症预后最差,生存率最短。这可能归因于许多变量,包括种族、生物学、社会经济和社会文化因素(单个、多个或综合因素),这些因素可能是导致这一重大健康问题的原因。我们试图评估危害非洲人民健康的最常见癌症类型,并试图调查非洲患者与其他非非洲患者在不同癌症的发病率、患病率和死亡率方面的实际差异。因此,确定导致非洲患者发病率和死亡率上升的潜在病因,将有助于改变当前的计划,为那些非洲患者制定优化的筛查、诊断和治疗方式,以提高他们的生存率和治疗效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e8e/7781064/9f4120e4e09a/fonc-10-604214-g001.jpg

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