van Eeden S F, Coetzee A R, Joubert J R
Diffuse Obstructive Pulmonary Syndrome Research Group of the South African Medical Research Council, University of Stellenbosch.
S Afr Med J. 1988 Jan 23;73(2):77-81.
The mortality rate in critically ill patients with pneumonia who require invasive vital organ support, including mechanical ventilation, in an intensive care unit (ICU) remains above 50%. The contribution of these costly life support systems to the survival of patients with extensive pneumonia is a matter for debate. The high mortality rate in this group of patients can be attributed in part to the fact that they are frequently referred for ICU care when their condition has already deteriorated to the point of no return. A retrospective study over 18 months of 34 cases of community-acquired pneumonia (17 patients required ventilatory support in the respiratory ICU) was undertaken to identify criteria which would justify early admission to an ICU. These were first-line clinical and biochemical factors, three of which were present in all patients on admission to hospital: (i) bronchopneumonia or lobar pneumonia involving more than two lobes (P less than 0.001); (ii) respiratory rate greater than 30/min (P less than 0.001); and (iii) partial arterial oxygen pressure less than 8 kPa (P less than 0.001). Other systemic factors associated with a poor prognosis and admission to the ICU were clinical signs of septicaemia, abnormal liver function and low serum albumin value. A scoring system for severity of pneumonia based on these factors is proposed. The possibility of an improved prognosis in a potentially reversible disease can become a reality if this approach is employed prospectively.
在重症监护病房(ICU)中,需要包括机械通气在内的侵入性重要器官支持的重症肺炎患者的死亡率仍高于50%。这些昂贵的生命支持系统对广泛肺炎患者生存的贡献存在争议。这组患者的高死亡率部分可归因于他们在病情已经恶化到无法挽回的地步时才经常被转诊到ICU进行治疗。对34例社区获得性肺炎患者进行了为期18个月的回顾性研究(17例患者在呼吸ICU需要通气支持),以确定可证明早期入住ICU合理的标准。这些是一线临床和生化因素,其中三项在所有入院患者中都存在:(i)支气管肺炎或大叶性肺炎累及两个以上肺叶(P<0.001);(ii)呼吸频率大于30次/分钟(P<0.001);(iii)动脉血氧分压低于8kPa(P<0.001)。与预后不良和入住ICU相关的其他全身因素包括败血症的临床体征、肝功能异常和血清白蛋白值低。基于这些因素提出了一种肺炎严重程度评分系统。如果前瞻性地采用这种方法,在潜在可逆性疾病中改善预后的可能性就可以成为现实。