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社区获得性肺炎——影响入住重症监护病房的因素

Community-acquired pneumonia--factors influencing intensive care admission.

作者信息

van Eeden S F, Coetzee A R, Joubert J R

机构信息

Diffuse Obstructive Pulmonary Syndrome Research Group of the South African Medical Research Council, University of Stellenbosch.

出版信息

S Afr Med J. 1988 Jan 23;73(2):77-81.

PMID:3340927
Abstract

The mortality rate in critically ill patients with pneumonia who require invasive vital organ support, including mechanical ventilation, in an intensive care unit (ICU) remains above 50%. The contribution of these costly life support systems to the survival of patients with extensive pneumonia is a matter for debate. The high mortality rate in this group of patients can be attributed in part to the fact that they are frequently referred for ICU care when their condition has already deteriorated to the point of no return. A retrospective study over 18 months of 34 cases of community-acquired pneumonia (17 patients required ventilatory support in the respiratory ICU) was undertaken to identify criteria which would justify early admission to an ICU. These were first-line clinical and biochemical factors, three of which were present in all patients on admission to hospital: (i) bronchopneumonia or lobar pneumonia involving more than two lobes (P less than 0.001); (ii) respiratory rate greater than 30/min (P less than 0.001); and (iii) partial arterial oxygen pressure less than 8 kPa (P less than 0.001). Other systemic factors associated with a poor prognosis and admission to the ICU were clinical signs of septicaemia, abnormal liver function and low serum albumin value. A scoring system for severity of pneumonia based on these factors is proposed. The possibility of an improved prognosis in a potentially reversible disease can become a reality if this approach is employed prospectively.

摘要

在重症监护病房(ICU)中,需要包括机械通气在内的侵入性重要器官支持的重症肺炎患者的死亡率仍高于50%。这些昂贵的生命支持系统对广泛肺炎患者生存的贡献存在争议。这组患者的高死亡率部分可归因于他们在病情已经恶化到无法挽回的地步时才经常被转诊到ICU进行治疗。对34例社区获得性肺炎患者进行了为期18个月的回顾性研究(17例患者在呼吸ICU需要通气支持),以确定可证明早期入住ICU合理的标准。这些是一线临床和生化因素,其中三项在所有入院患者中都存在:(i)支气管肺炎或大叶性肺炎累及两个以上肺叶(P<0.001);(ii)呼吸频率大于30次/分钟(P<0.001);(iii)动脉血氧分压低于8kPa(P<0.001)。与预后不良和入住ICU相关的其他全身因素包括败血症的临床体征、肝功能异常和血清白蛋白值低。基于这些因素提出了一种肺炎严重程度评分系统。如果前瞻性地采用这种方法,在潜在可逆性疾病中改善预后的可能性就可以成为现实。

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引用本文的文献

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Risk factors and severity scores in hospitalized patients with community-acquired pneumonia: prediction of severity and mortality.住院社区获得性肺炎患者的危险因素和严重程度评分:严重程度和死亡率的预测。
Eur J Clin Microbiol Infect Dis. 2012 Jan;31(1):33-47. doi: 10.1007/s10096-011-1272-4. Epub 2011 May 1.
2
Analysis of factors that contribute to treatment failure in patients with community-acquired pneumonia.社区获得性肺炎患者治疗失败的相关因素分析
Eur J Clin Microbiol Infect Dis. 2006 Mar;25(3):159-66. doi: 10.1007/s10096-006-0113-3.
3
BTS Guidelines for the Management of Community Acquired Pneumonia in Adults.
英国胸科学会成人社区获得性肺炎管理指南
Thorax. 2001 Dec;56 Suppl 4(Suppl 4):IV1-64. doi: 10.1136/thorax.56.suppl_4.iv1.
4
Severity prediction rules in community acquired pneumonia: a validation study.社区获得性肺炎严重程度预测规则:一项验证研究。
Thorax. 2000 Mar;55(3):219-23. doi: 10.1136/thorax.55.3.219.
5
Impact of management guidelines on the outcome of severe community acquired pneumonia.管理指南对重症社区获得性肺炎结局的影响
Thorax. 1997 Jan;52(1):17-21. doi: 10.1136/thx.52.1.17.
6
Severe community-acquired pneumonia in ICUs: prospective validation of a prognostic score.
Intensive Care Med. 1996 Dec;22(12):1307-14. doi: 10.1007/BF01709543.
7
Quality of published reports of the prognosis of community-acquired pneumonia.社区获得性肺炎预后已发表报告的质量
J Gen Intern Med. 1994 Jan;9(1):13-9. doi: 10.1007/BF02599136.
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A five-year study of severe community-acquired pneumonia with emphasis on prognosis in patients admitted to an intensive care unit.
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