Wodeyar Anirudh, Cassidy Jessica M, Cramer Steven C, Srinivasan Ramesh
Department of Cognitive Sciences, University of California, Irvine, CA, USA.
Department of Allied Health Sciences, University of North Carolina, Chapel Hill, NC, USA.
Netw Neurosci. 2020 Dec 1;4(4):1197-1218. doi: 10.1162/netn_a_00160. eCollection 2020.
The relationship between structural and functional connectivity has been mostly examined in intact brains. Fewer studies have examined how differences in structure as a result of injury alters function. In this study we analyzed the relationship of structure to function across patients with stroke among whom infarcts caused heterogenous structural damage. We estimated relationships between distinct brain regions of interest (ROIs) from functional MRI in two pipelines. In one analysis pipeline, we measured functional connectivity by using correlation and partial correlation between 114 cortical ROIs. We found fMRI-BOLD partial correlation was altered at more edges as a function of the structural connectome (SC) damage, relative to the correlation. In a second analysis pipeline, we limited our analysis to fMRI correlations between pairs of voxels for which we possess SC information. We found that voxel-level functional connectivity showed the effect of structural damage that we could not see when examining correlations between ROIs. Further, the effects of structural damage on functional connectivity are consistent with a model of functional connectivity, diffusion, which expects functional connectivity to result from activity spreading over multiple edge anatomical paths.
结构连接性与功能连接性之间的关系大多是在完整大脑中进行研究的。较少有研究探讨损伤导致的结构差异如何改变功能。在本研究中，我们分析了中风患者中结构与功能之间的关系，这些患者的梗死灶造成了异质性的结构损伤。我们通过两种流程从功能磁共振成像（fMRI）中估计了不同感兴趣脑区（ROI）之间的关系。在一种分析流程中，我们通过使用114个皮质ROI之间的相关性和偏相关性来测量功能连接性。我们发现，相对于相关性，功能磁共振成像血氧水平依赖（fMRI-BOLD）偏相关性作为结构连接组（SC）损伤的函数，在更多边缘处发生了改变。在第二种分析流程中，我们将分析限制在具有SC信息的体素对之间的fMRI相关性上。我们发现，体素水平的功能连接性显示出结构损伤的影响，而在检查ROI之间的相关性时我们并未看到这种影响。此外，结构损伤对功能连接性的影响与功能连接性的扩散模型一致，该模型预计功能连接性是由活动在多条边缘解剖路径上传播产生的。
