Department of Neurology, University of California, Irvine, 200 S. Manchester Ave., Suite 206, CA, 92868, Orange, USA.
Transl Stroke Res. 2021 Jun;12(3):369-381. doi: 10.1007/s12975-020-00879-w. Epub 2021 Jan 6.
In the past 5 years, the success of multiple randomized controlled trials of recanalization therapy with endovascular thrombectomy has transformed the treatment of acute ischemic stroke with large vessel occlusion. The evidence from these trials has now established endovascular thrombectomy as standard of care. This review will discuss the chronological evolution of large vessel occlusion treatment from early medical therapy with tissue plasminogen activator to the latest mechanical thrombectomy. Additionally, it will highlight the potential areas in endovascular thrombectomy for acute ischemic stroke open to exploration and further progress in the next decade.
在过去的 5 年中，多次血管内血栓切除术再通治疗的随机对照试验取得了成功，改变了大血管闭塞性急性缺血性脑卒中的治疗方法。这些试验的证据现在已经确立了血管内血栓切除术作为标准治疗。本综述将讨论从早期使用组织型纤溶酶原激活物的药物治疗到大血管闭塞治疗的时间顺序演变，到最新的机械血栓切除术。此外，它还将突出强调血管内血栓切除术在急性缺血性脑卒中治疗方面的潜在探索领域，并展望未来十年的进一步进展。
