Govindarajan S, Fong T L, Valinluck B, Edwards V, Redeker A G
University of Southern California Liver Unit, Department of Pathology and Medicine, Rancho Los Amigos Medical Center, Downey 90242.
Am J Clin Pathol. 1988 Feb;89(2):233-7. doi: 10.1093/ajcp/89.2.233.
Serum samples from 56 patients with biopsy-proven chronic B viral hepatitis without superimposed delta hepatitis were analyzed for the various markers of viral replication, including serum hepatitis B e Ag (HBeAg), hepatitis B virus deoxyribonucleic acid (HBV-DNA), and hepatitis B core antigen (HBcAg) in the liver tissues. Twenty-seven patients had persistent viral hepatitis (PH) and 29 patients had chronic active hepatitis (CAH) with or without cirrhosis. HBV-DNA was identified in the sera of 81% of patients with PH and 60% of patients with CAH. Significantly higher levels of HBV-DNA were found in patients with PH than in those with CAH. Both HBeAg in serum and HBcAg in liver correlated positively with serum HBV-DNA. Nine patients had serum HBV-DNA in the absence of HBeAg (four had anti-HBe), and seven of these nine patients had stainable HBcAg in the liver (two did not have staining). None of these patients had hepatic HBcAg in the absence of serum HBV-DNA. When these patients were stratified according to their epidemiologic background, serum HBV-DNA was present in a significantly higher number of male homosexuals than in any other groups. This was unrelated to their status of human immunodeficiency viral serology.
对56例经活检证实为慢性乙型病毒性肝炎且无重叠丁型肝炎的患者血清样本进行分析，检测各种病毒复制标志物，包括血清乙肝e抗原（HBeAg）、乙肝病毒脱氧核糖核酸（HBV-DNA）以及肝组织中的乙肝核心抗原（HBcAg）。27例患者为持续性病毒性肝炎（PH），29例患者为慢性活动性肝炎（CAH），伴有或不伴有肝硬化。81%的PH患者和60%的CAH患者血清中检测到HBV-DNA。PH患者的HBV-DNA水平显著高于CAH患者。血清中的HBeAg和肝脏中的HBcAg均与血清HBV-DNA呈正相关。9例患者血清中存在HBV-DNA但无HBeAg（4例有抗-HBe），这9例患者中有7例肝脏中可检测到HBcAg（2例未检测到染色）。这些患者中无一例在血清无HBV-DNA时肝脏中有HBcAg。当根据患者的流行病学背景进行分层时，男性同性恋者血清中HBV-DNA的检出率显著高于其他任何组。这与他们的人类免疫缺陷病毒血清学状态无关。
